Journal of Biochemistry and Molecular Biology (한국생화학회지)

Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Studies on the Antioxidant Components of Korean Ginseng(V): The Mechanism of Antioxidant Activity of Maltol and Phenolic acid

인삼의 항산화 활성성분에 관한 연구(V): Maltol과 Phenolic acid류의 항산화 활성의 메카니즘

  • Han, Byung-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Park, Myung-Hwan (Natural Products Research Institute, Seoul National University) ;
  • Han, Yang-Nam (Natural Products Research Institute, Seoul National University)
  • Received : 1985.08.12
  • Published : 1985.12.30

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Abstract

The effects of maltol and phenolic acids on lipid peroxidation of liver homogenate were studied. Gallic acid and protocatechuic acid showed more potent inhibitory effect on lipid peroxidation on in vitro system than maltol and other phenolic acids tested. However, when they were administered orally maltol was more effective than gallic acid. Acceleration of the lipid peroxidation by ferric ion was completely suppressed when the liver homogenate was treated by ferric ion in the presence of two moles of maltol. The molar ratio of maltol to ferric ion in the chelate was determined as being two to one by the dilution and continuous variation method. Based on the results, we are proposing one plausible mechainism for the antioxidant activity of maltol that maltol will deprive ferric ion by forming chelate from the initiating complex of microsomal NADPH dependent peroxide generating system.

간호모게네이트의 지질과산화에 미치는 maltol과 phenolic acid의 효과를 연구하였다. In vitro 실험계에서는 gallic acid와 protocatechuic acid가 maltol이나 기타 다른 phenolic acid을 보다 항산화 활성이 강하였다. 그러나 이들 물질을 동물에 정구투여 하였을 때의 항산화 활성은 gallic acid보다 maltol이 더 강하였다. 간호모게네이트에 $Fe^{+++}$이온을 첨가하여 야기되는 지질과산화의 촉진현상은 2 mol의 maltol이 첨가되었을 해는 완전히 억제되었다. Maltol과 $Fe^{+++}$로 구성되는 chelate 중의 분자비는 2 : 1로 측정되었다. 이와 같은 실험사실에 근거하여 maltol은 $Fe^{+++}$과 chelate를 형성함을 통하여 마이크로종에 있는 NADPH 의존성과 산화물 생성계에서 개시인자로 필요로하고 있는 $Fe^{+++}$를 탈취함으로써 항산화 활성을 발휘할 가능성을 제시한다.

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