Archives of Pharmacal Research
- Volume 8 Issue 4
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- Pages.277-282
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- 1985
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effects of antitumor polysaccharides from albizza julibrissin on immune function
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Moon, Chang-Kiu
(College of Pharmacy, Seoul National University)
;
- Lee, Byeong-Gon (College of Pharmacy, Seoul National University) ;
- Lee, Soo-Hwan (College of Pharmacy, Seoul National University) ;
- Kang, Tak-Lim (Department of Oriental Medicine, Dae-Jeon College)
- Published : 1985.12.01
Abstract
Polysaccharide fractions were prepared from Albizzia julibrissin by different extraction schedules. The fractions obtained were designated as PS-I and PS-II, respectively. Further purification of PS-I by Sephadex G-200 column chromatography gave two subfractions, Alju A and alju B, Each fraction showed marked antitumor activity against sarcoma 180 solid form but not ascite form. PS-I and PS-II increased delayed hypersensitivity in normal and tumor bearing mice. PS-I treatment led to moderate restoration of the suppressed antibody production in tumor bearing mice.
Keywords
- Polysaccharide;
- Albizzia julibrissin;
- Antitumor activity;
- Hemolytic plaque assay;
- Delayed hypersensitivity test