Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effects of Ginseng Saponin Fraction and Cyclophosphamide on the Tumoricidal Activity of Mouse Macrophage and the Antitumor Effect

생쥐의 대식세포 종양치사활성과 항암효과에 미치는 인삼 Saponin 분획물과 Cyclophosphamide의 영향

  • Jeon, Hye-Gyeong (Dept, of Biology. College of Science, Younsei Univ) ;
  • Kim, Se-Chang (Department of Biology, Paichai University) ;
  • Jeong, No-Pal (Department of Biology, College of Science, Yonsei University)
  • 전혜경 (연세대학교 이과대학 생물학과) ;
  • 김세창 (배재대학교 생물학과, 연세대학교 이과대학 생물학과) ;
  • 정노팔 (연세대학교 이과대학 생물학과)
  • Published : 1991.08.01
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Abstract

This experiment was performed to investigate the effects of ginseng saponin fraction and cyclophosphamide (CY) on the tumor development, the antitumor effect and the tumoricidal activity of mouse macrophage. When mice were treated with saponin or CY following inoculation with Sarcoma 180, tumor development was inhibited and survival ratio increased, and a combination of both treatments further inhibited the tumor development. Tumoricidal activity of macrophage was effectively increased at 10-7% concentration of CY and it was further increased when macrophage was cotreated with saponin and CY. Tumoricidal activity of macrophage was greatest at the third day after inoculating tumor cell. Both saponin and CY increased the chemiluminescence of macrophage, but CY had no effect on releasing TNF, unlike saponin.

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