Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Pharmacological, Toxicological Studies of Antitumor Polysaccharides Obtained from Ganoderrna lucidurn IY 009

Ganoderma lucidum IY 009로 부터 분리된 항암성 다당류의 약리 및 독성

  • Lee, Kweon-Haeng (Department of Food Engineering, College of Engineering, Yonsei University, Bioproducts Research Center) ;
  • Lee, Chong-Ock (Pharmacological Screening Lab., Korea Research Institute of Chemical Technology) ;
  • Lee, June-Woo (Biotechnology Lab., Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Jeong, Hoon (Biotechnology Lab., Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Han, Man-Deuk (Biotechnology Lab., Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Jeong, June-Ho (Biotechnology Lab., Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Oh, Doo-Hwan (Department of Food Engineering, College of Engineering, Yonsei University, Bioproducts Research Center)
  • 이권행 (연세대학교 식품생물공학과 생물산업소재연구센터) ;
  • 이정옥 (한국화학연구소 의약활성연구실) ;
  • 이준우 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 정훈 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 한만덕 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 정준호 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 오두환 (연세대학교 식품생물공학과 생물산업소재연구센터)
  • Published : 1994.04.01
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Abstract

The highest antitumor activity was observed in water soluble AS fraction of the Ganoderma lucidum IY 009. AS fraction did not show any cytotoxicity on sarcoma 180 cell but stimulated antibody production, opsonization of macrophage in ICR mouse and superoxide ion production from isolated macrophage. AS fraction activated complement C3 in human serum, and their antitumor activity was inhibited by EDTA, a chelator of cation related complementary activation. AS fraction exerted om prolong of life span and ingibition of tumor growth in the leukemia P388 or L1210 transplanted inbreed mouse,k BDF1 but krestin did not. AS fraction did not show any serious and lethal effects through oral administration on ICR mouse, and LD$_{50}$ of those was above 2,230 mg/kg.

Keywords

References

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