한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)
- 제9권3호
- /
- Pages.163-168
- /
- 1994
- /
- 1229-1153(pISSN)
- /
- 2465-9223(eISSN)
캡사이신과 그 합성유도체의 기니픽 기관지 평활근에 대한 작용
Effect of Capsaicin and Its Novel Derivative on the Isolated Guinea Pig Bronchi
초록
In the present study we investigated the peripheral function of capsaicin and KR-25018, a newly synthesized capsaicin derivative, which was demonstrated to have a potent analgesic activity through different mechanism from morphine and nonsteroidal antiinflammatory drugs. Capsaicin (10-8~10-5 M) and KR-25018 (10-8~10-5 M) produced concentration-dependent contractions of the isolated guinea pig bronchi. There were no significant differences in the maximum response and the EC50 values (EC50: 0.137