Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antithrombotic Effects of Some Traditional Plant Medicines

수종 생약의 항혈전활성

  • YunChoi, Hye-Sook (Natural Products Research Institute, Seoul National University) ;
  • Chung, Kyo-Soon (Natural Products Research Institute, Seoul National University) ;
  • Kim, Moon-Hee (Natural Products Research Institute, Seoul National University) ;
  • Oh, Jay-Hee (Natural Products Research Institute, Seoul National University)
  • 윤혜숙 (서울대학교 천연물과학연구소) ;
  • 정교순 (서울대학교 천연물과학연구소) ;
  • 김문희 (서울대학교 천연물과학연구소) ;
  • 오재희 (서울대학교 천연물과학연구소)
  • Published : 1995.06.30
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Abstract

Twentyfive plant crude drugs with traditional reputation were selected for the antithrombotic screening. MeOH (80%) extract of each plant was given (500 mg/Kg, p.o.) to mice 1 hr prior to the thrombotic challenge (1.8 mg collagen plus 180 ug epinephrine/Kg, i.v.). Seven extracts (1, 2, 8, 10, 18, 22 and 23) showed either comparable or better recovery than aspirin (50 mg/Kg, p.o.) from paralysis caused by the pulmonary thrombosis. 1, 2, 8, 10, 18, 22 and 23 were fractionated to $CH_2Cl_2$ soluble (fr I) and $H_2O$ soluble (fr II) fractions and each fraction (100 mg/Kg, p.o.) was also tested. Mice treated with fr I of 2 (Angelica koreana), 10 (Corydalis spp.) or 23 (Schizonepeta tenuifolia) showed higher recovery and lower mortality rates than aspirin (50 mg/Kg, p.o.) treated mice.

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