Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-platelet and Anti-thrombotic Effects of Gastrodia elata

천마(Gastrodia elata Blume)의 항혈소판, 항혈전활성

  • 백영숙 (경희대학교 화학과) ;
  • 송재경 (경희대학교 화학과) ;
  • 윤춘희 (서울대학교 천연물과학연구소) ;
  • 정교순 (서울대학교 천연물과학연구소) ;
  • 윤혜숙 (서울대학교 천연물과학연구소)
  • Published : 1995.12.30
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Abstract

MeOH extract of Gastrodia elata was fractionated to five solvent fractions, hexane fr (fr I), 90% MeOH fr (fr II), EtOAc fr (fr III), BuOH fr (fr IV) and $H_2O$ fr (fr V). Among the five fractions, fr II, III and IV showed platelet anti-aggregating effects against ADP or collagen induced rat platelet aggregation in vitro. Fr II , III and IV were also tested in vivo, in the mouse and rat models of thrombosis. Oral administration of fr II, III or IV enhanced the recovery from the thrombotic shock in the mouse model of thrombosis to 32-40% from 17% of recovery with the control group of mice. Treatment with fr II, III or IV also attenuated the sudden reduction in the blood platelet count following intravenous collagen injection to rat. The above results were indicative of the presence of anti-platelet and anti-thrombotic components in this plant.

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