Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Bovine Ash and Calcium Phosphate on Calcium Metabolism in Postmenopausal Osteoporosis Model Rats

골다공증 실혐모델 흰쥐의 칼슘대사에 대한 소뼈회분과 인산칼슘의 섭취 효과

  • 이연숙 (서울대학교 농업생명과학대학 농가정학과)
  • Published : 1995.06.01
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Abstract

The model rats with postmenopausal osteoporosis were comparatively observed with regard to the effects of bovine ash and calcium phosphate on calcium metabolism. The modelling design involved the five week-old week-old female SD-strain rats ovariectomized and fed a low-Ca diet(20% casein, 0.06% Ca and 0.38% P) for three weeks. The rats were divided into five groups, one of which was fed the low-Ca diet(basal), and the rest of which were divided into five groups, one of which was fed the low-Ca diet(basal), and the rest of which were fed four kinds of Ca-supplemental diets(20% protein, 1.06% Ca and 0.8% P) for three weeks. The Ca-suplements diets contained two kinds of Ca sources, bovine bone ash(BBA) or calcium phosphate, tribasic [Ca3(PO4)2] and two kinds of protein sources, casein or isolated soy protein(ISP). The model rats of postmenopausal osteoporosis fed basal diet showed a significant decrease in Ca utilization in reference to serum Ca concentration, breaking force of bone, Ca and P contents of bone, and Ca absorption and retention. However, the supply of Ca for three weeks demonstrated the improved utilization of Ca. One step further, BBA was more effective than calcium phosphate in improving Ca utilization in ISP-fed groups. On the other hand, no significant difference was seen in casein-fed groups. It is to conclude that BBA could be more effective in accelerating Ca utilization under vulnerable dietary or physiological conditions such as vegetable protein intake and osteoprosis.

Keywords

References

  1. Modern Nutrition in Health and Disease(8th ed.) Calcium and phosphorus Allen,L.H.;Wood,R.J.;Shils,M.E.(ed.);Olson,J.A.(ed.);Shike,M.(ed.)
  2. Clinics in Applied Nutrition Calcium, Vitamin D and Colon cancer Scalmati,A.;Lipkin,M.;Newmark,H.;Chernoff,R.(ed.);Heaney,R.P.(ed.)
  3. Ann Rev Nutr v.13 Nutritional factors in osteoporosis Heaney,R.P.
  4. Am J Clin Nutr Calcium absorbability from milk products, and imitation milk and calcium carbonate Recker,R.R.;Bammi,A.;Barger-Lux,J.;Heaney,R.P.
  5. J Jpn Soc Nutr Food Sci v.40 Comparison of three kinds of Ca compouds with regard to their bioavailability as Ca source Kobayashi,T.;Okano,T.;Masuda,S.
  6. J Jpn Soc Nutr Food Sci v.44 Effects of bovine bone powder and calcium carbonate as a dietary calcium source on plasma and bone calcium metabolism in rats Okano,T.;Tsugawa,N.;Higashino,R.(et al.)
  7. J Nutr v.117 Mineral utilization by rats fed various commericially available calcium supplements or milk Greger,J.L.;Krzykowski,C.E.;Khazen,R.R.;Krashoc,C.L.
  8. Jap J Home Econo v.38 Studies on calcium metabolism Ezawa,I.
  9. J Bone Miner Met v.12 Effects of casein phosphopeptide on absorbability of co-ingested calcium in normal postmenopausal women Heaney,R.P.;Saito,Y.;Orimo,H.
  10. J Jpn Soc Nutr Food Sci v.45 Supplemental effect of casein phosphopeptide(CPP) on the calcium balance of growing rats Lee,Y.S.;Park,J.A.;Naito,H.
  11. 한국영양학회지 v.27 칼숨공급원으로서 건멸치, 두부, 탈지분유의 체내이용성 연구 이성현;장순옥
  12. 한국영양학회지 v.26 난소절제 골다공증 모델 흰쥐의 체내 칼슘 이용성 저하에 대한 칼슘섭취 수준의 효과 오주환;이연숙
  13. 한국농촌생활과학회지 v.3 칼슘급원으로서 소뼈회분 및 소뼈분말의 체내이용성 연구 이연수;박정희;오주환;최창원
  14. Br J Nutr v.43 Phosphopeptides and soluble calcium in the small intestine of rats given a casein diet Lee,Y.S.;Noguchi,T.;Naito,H.
  15. J Bio Chem v.66 The colorimetric determination of phosphorus Fisk,C.H.;Subbarow,Y.
  16. Clinical biochemical and hematological reference values in normal experimental animals and normal humans(2nd Ed.) Clinical biochemical reference value Mitruka,B.M.;Rawnsley,H.M.
  17. J Jpn Soc Nutr Food Sci v.45 The effect of globin powder on bone mineral density in model rats with postmenopausal osteporosis Omi,N.;Morikwa,N.;Hoshina,A.;Ezawa,I.
  18. Jap J Home Econo v.34 The effect of cow bone powder on osteopenia of rat model of postmenopausal osteoporosis Ezawa,I.;Arai,F.