Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

A Component from Cornus officinalis Enhances Hydrogen Peroxide Generation from Macrophages

산수유의 반응성 산소종 생성 증진 성분

  • Kim, Dae-Keun (College of Pharmacy, Sung Kyun Kwan University) ;
  • Kwak, Jong-Hwan (College of Pharmacy, Sung Kyun Kwan University) ;
  • Ryu, Jung-Hee (College of Pharmacy, Sung Kyun Kwan University) ;
  • Kwon, Hak-Chul (College of Pharmacy, Sung Kyun Kwan University) ;
  • Song, Ki-Won (College of Pharmacy, Sung Kyun Kwan University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University) ;
  • Lee, Sung-Haeng (Department of Biochemistry, College of Medicine, Chung-Ang University) ;
  • Lee, Eun-Ah (Department of Biochemistry, College of Medicine, Chung-Ang University) ;
  • Kwon, Nyoyn-Soo (Department of Biochemistry, College of Medicine, Chung-Ang University) ;
  • Lee, Kang-Ro (College of Pharmacy, Sung Kyun Kwan University) ;
  • Zee, Ok-Pyo (College of Pharmacy, Sung Kyun Kwan University)
  • 김대근 (성균관대학교 약학대학) ;
  • 곽종환 (성균관대학교 약학대학) ;
  • 류정희 (성균관대학교 약학대학) ;
  • 권학철 (성균관대학교 약학대학) ;
  • 송기원 (성균관대학교 약학대학) ;
  • 강삼식 (서울대학교 천연물과학연구소) ;
  • 이성행 (중앙대학교 의과대학 생화학교실) ;
  • 이은아 (중앙대학교 의과대학 생화학교실) ;
  • 권년수 (중앙대학교 의과대학 생화학교실) ;
  • 이강노 (성균관대학교 약학대학) ;
  • 지옥표 (성균관대학교 약학대학)
  • Published : 1996.06.30
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Abstract

Hydrogen peroxide is one of major chemicals mediating antitumor and antimicrobial activities of macrophages. We searched natural products enhancing hydrogen peroxide generation from murine macrophage-like cell line J774. Among 21 methanol extracts of Korean medicinal plants, the extract from Cornus officinalis was the most effective. The active component from the fractions was searched by activity guided fractionation, and identified as ursolic acid by spectral data.

Keywords