Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Eye Irritation, Skin Irritation and Skin Sensitization Tests for Aloewhite in Animals

Aloewhite의 안점막 및 피부에 대한 국소자극시험

  • 김형식 (성균관대학교 약학대학 독성학연구실) ;
  • 곽승준 (성균관대학교 약학대학 독성학연구실) ;
  • 김규봉 (성균관대학교 약학대학 독성학연구실) ;
  • 이승기 (성균관대학교 약학대학 독성학연구실) ;
  • 박현선 (성균관대학교 약학대학 독성학연구실) ;
  • 홍채영 (성균관대학교 약학대학 독성학연구실) ;
  • 안미영 (성균관대학교 약학대학 독성학연구실) ;
  • 조태형 (남양알로에 중앙연구소) ;
  • 오선택 (남양알로에 중앙연구소)
  • Published : 1996.06.01
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Abstract

Eye irritation, primary skin irritation and skin sensitization tests for Aloewhite were tested in New Zealand White rabbits and Hartley guinea pig. In primary skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and Primary Irritation Index (PII) was O.47, indicating Aloewhite as mildly irritating material. In ocular irritation test, any injury on iris, conjunctival membrane, and cornea in New Zealand White rabbits was not observed. No injuries of the ocular mucous membrane were also recorded. Skin sensitization was tested in guinea pig after intradermal and epicutaneous induction and graded 1 with zero % sensitization rate. These results indicate that Aloewhite was not considered to be irritant in test organs of animals.

Keywords

References

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