항진균성 항생물질을 생산하는 streptoverticillium sp. NA-4803의 분리 및 동정

  • 임대석 (건국대학교 동물자원연구센터 분자세포생물학교실) ;
  • 윤상군 (한국야쿠르트 중앙연구소) ;
  • 이명섭 (건국대학교 동물자원연구센터 분자세포생물학교실) ;
  • 윤원호 (서일전문대학 식품가공학과) ;
  • 김창한 (건국대학교 동물자원연구센터 분자세포생물학교실)
  • Published : 1996.12.01

Abstract

The aim of the present research program was to develop a strain of actinomycetes producing antifungal substance. Soil samples were collected from various sites in Korea and a number of actinomycetes were isolated from the soil samples by applying selective agar for actinomycetes. Among over 440 isolates, a strain (NA-4803) producing antifungal substance against Trichophyton spp. Nannizzia otae and Pyricularia oryzae was selected. The strain NA-4803 was identified as strain similar to Streptoverticillium blastmyceticum with respect to morphological and physiological characteristics, lecithinase and lipolytic activity, degradation of organic compounds, resistance to antibiotics and utilization of carbon and nitrogen sources. But it showed some differences such as positive reaction of nitrate reduction, negative reaction of L-tyrosine degradation, resistance to cephaloridine, and utilization of I -rhamnose and inulin. The strain NA-4803 was named as Streptoverticillium sp. NA-4803.

Keywords

References

  1. Method in Enzymology v.63 Cultural conditions for antibiotic-producing microorganisms Porter,J.N.;John H. Hash(ed.)
  2. Antibiotics in laboratory medicine Antifungal drugs McGinnis,M.R.;M.G.Rinaldi;Victor Lorian, M.D.(ed.)
  3. J. Microbiol. and Biotechnol. v.2 Antifungal activity of Serratia marcescens culture extracts against phytopathogenic fungi (possibility for the chitinases role) Lee,S.Y.;W.G.Sang;J.R.Hwang;H.W.Yoon;Y.C.Shin;M.J.Cho
  4. 한국산업미생물학회지 v.21 Streptomyces neyagawaensis 38D10 균주가 생산하는 concanamycin B의 항고 추역병 활성 김창진;이인경;윤봉식;유익동
  5. 한국산업미생물학회지 v.18 Streptomyces melanosporofaciens가 생산하는 새로운 항생물질 1. 생산균주의 분류 김창한;김시관;김상석
  6. Int. J. Syst. Bacteriol. v.16 Methods for the characterization of Streptomyces species Shirling,E.B.;D.Gottlieb
  7. J. Gen. Microbiol. v.129 A probability matrix for the identification of some streptomycetes Williams,S.T.;M.Goodfellow;E.M.H.Wellington;J.C.Vickers;G.Alderson;P.H.A.Sneath;M.Sackin;A.M.Mortimer
  8. J. Gen. Microbiol. v.129 Numerical classification of streptomyces and related genera. Williams,S.T.;M.Goodfellow;G.Alderson;E.M.H.Wellington;P.H.A.Sneath;M.Sackin
  9. Int. J. Syst. Bacteriol. v.16 Methods for characterization of Streptomyces species. Shirling,E.B.;D.Gottlieb
  10. J. Antibiot. v.11 A simple method for microscopical observation of streptomycetes and critique of Streptomyces grouping with reference to aerial structure Okami,Y.;M.Suzuki.
  11. J. Gen. Appl. Microbiol. v.16 Taxonomic studies on Coryneform bacteria. Ⅱ. Principle amino acids in the cell wall and their taxonomic significance Yamada,K.;K.Kamagata
  12. Appl. Microbiol. v.28 Simplified approach to identification of aerobic actinomycetes by thinlayer chromatograph Staneek,J.L.;G.D.Robert.
  13. Experimentia v.25 Egg-yolk agar as a diagnostic medium for Streptomyces Nitsch,B.;H.J.Kutzner
  14. Actinomycete taxonomy(special publication 6) The Chemotaxonomy of actinomycetes Lechevalier,H.A.;M.P.Lechevalier;A.Dietz(ed.);D.W.Thayer(ed.)
  15. Giornale di microbiologia v.14 Emendation of the genus Streptoverticillium Baldacci (1958) and revision of some species Baldacci,E.;G.Farina;R.Locci
  16. Int. J. Syst. Bacteriol. v.18 Cooperative description of type cultures of Streptomyces.Ⅱ. Species descriptions from first study Shirling,E.B.;D.Gottlieb
  17. J. Nat. Prod. v.57 New teleocidin-related metabolites, (-)-7-geranylindolactam-V and blastmycetin F, from Streptoverticillium blastmyceticum Irie,K.;S.Kajiyama;S.Okuno;M.Kondo;A.Iwashima
  18. Tetrahedron Lett. v.30 Structure of blastmycetin E. a new telcocidinrelated compound, from Streptoverticillium blastmyceticum Irie,K.;A.Funaki;K.Koshimizu;H.Hayashi;M.Arai
  19. Agric. Biol. Chem. v.51 Isolation of blastmycetin D, a possible precursor of teleocidins, from Streptoverticillium blastmyceticum Irie,K.;N.Hagiwara;A.Funaki;H.Hayashi;M.Arai;K.Koshimizu
  20. Appl. Microbiol. v.2 Classification of Streptomyces spore surfaces into five groups Dietz,A.;J.Mathews
  21. Appl. Microbiol. v.12 Rapid differentiation between Norcardia and Streptomyces by paper chromatography of whole-cell hydrolysates Becker,B.;M.P.Lechevalier;R.E.Gordon;H.A.Lcchcvalier
  22. Bergey's Manual of Systematic Bacteriology v.4 Supregentric classification of actinomycetes Goodfellow,M.;Williams,S.T.(ed.);Elisabeth Sharpe, M.(ed.);Holt,J.G.(ed.)
  23. J. Gen. Microbiol. v.112 Numerical taxonomy of Actinomadura and related actinomycetes Goodfellow,M.;G.Alderson;J.Lacey
  24. J. Gen. Microbiol. v.83 Antibiotic sensitivity of some nocardioform bacteria and its value as a criterion for taxonomy Goodfellow,M.;V.A.Orehard
  25. Handbook of Microbiology(2nd ed.) v.9 Antibiotics produced by actinomycctes Lechevalier,H.A.;Y.Okami;M.Arai;Laskin,A.I.(ed.);Lechevalier,H.A.(ed.)
  26. Int. J. Syst. Bacteriol. v.20 Chemical composition as a criterion in the classification of acrobic actinomycetes Lechevalier,M.P.;H.A.Lechevalier
  27. Bergey's Manual of Systematic Bacteriology v.4 Streptomycetes and related genera Locci,R.;Williams,S.T.(ed.);Elisabeth Sharpc, M.(ed.);Holt,J.G.(ed.)
  28. Clinical and Experimental Dermatology v.20 Topical sphingolipids in antisepsis and antifungal therapy Bibel,D.J.;R.Aly;H.R.Shinefield
  29. J. Gen. Microbiol. v.77 Identification of bacteria by computer: theory and programming Willcox,W.R.;S.P.Lapage;S.Bascomb;M.A.Curtis
  30. J. Ferment. Technol. v.47 The distribution of actinomycetes in soil. Ⅳ. A selective plate-culture isolation method for Microbispora and Streptosporangium strains Nonomura,H.;Y.Ohara