Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Antihypertensive Diets Mainly Consisting of Buckwheat, Potato, and Perilla Seed on Blood Pressures and Plasma Lipids in Normotensive and Spontaneously Hypertensive Rats

메밀, 감자, 들깨를 이용한 항고혈압 기능성 식이가 정상혈압쥐 및 본태성고혈압쥐에서 혈압 및 혈장지질에 미치는 영향

  • 한찬규 (한국식품개발연구원 축산물이용연구부)
  • Published : 1996.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The study was carried out to investigate a new type of functional foods with hypotensive effect which is critical in the prevention and treatment of hypertension and related circulatory diseases. The experimental diets(A, B, C) were prepared from plant based ingredients such as buckwheat, potato, perilla seed with different ratios formulated as an edible form appropriate for human consumption according to AIN-77 standard. Control group(D) was fed commercial rat chow. Twety-four 15-week-old SDR(Sprague Dawley rats) and twenty-four 20-week-old SHR(spontaneously hypertensive rats), weighing 200g respectively, were assigned to 4 treatments of 6 rats each in a completely randomized design. Blood pressure was measured at 7 day interval by tail-cuff sphygmomanometer using an IITC cuff pump and amplifier. The growth rates of both SHR and SDR were not statistically different in comparions with the control except those of diet B and C in SDR and SHR, respectively(p<0.05). When exprimental diets were fed, systolic blood pressure of SDR and SHR at day 28 had been lowered by 17-20 mmHg(ave. of 19.6mmHg for both strains) compared with the reference pressure at day 0. The levels of HDL-cholesterol were increased, while the levels of LDL-cholesterol consistently decreased in both strains when experimental diets were fed(p<.05). Plasma total cholesterol levels were not different among treatments. Plasma triglyceride levels were higher in control diet(commercial rat chow) due to two times higher fat content of control diet itself(p<.05). Atherogenic indices were lower compared to those of control when the experimental diets were fed in both strains (p,.05). The results suggest that the antihypertensive diets mainly consisting of plant-based ingredients may possibly effective in relieving hypertension as well as circulatory diseases.

Keywords

References

  1. Can. J. Anim. Sci. Chemical composition and nutritive value of buckwheat cultivate for laboratory rats Thacter,P.A.;Anderson,D.M.;Bowland,J.P.
  2. Arch Intern. Med. v.146 Sodium and hypertension Houston,M.C.
  3. Br. J. Acaesthesia v.56 Aetiology of hypertension Swales,F.D.
  4. Am. J. Clin. Nutr. v.45 Dietary salt and risk to health Joossens,J.V.;Geboers,J.
  5. Lab. Invest. v.13 Agumented salt ingestion and its upon salt hypertension and adrenal-regenerated hypertension Hall,C.E.;Hall,O.
  6. 대한의학협회지 v.28 고혈압의 성인에 대한 최근학설 김삼수
  7. 한국식품과학회지 v.22 메밀 및 메밀식품에서의 루틴함량의 분석 맹영선;박혜경;권태봉
  8. 한국영양식량학회지 v.20 메밀 보충급여가 백서의 혈당 및 혈압에 미치는 영향 최면;김종대;박경숙;오상룡;이상영
  9. 한국영양학회지 v.26 no.7 들깨유 급원의 Linolenic Acid 섭취 증가가 흰쥐의 혈청지질 감소 및 항혈전에 미치는 효과 정혜림;한용남;김숙희
  10. Br. J. Nutr. v.68 Hypocholesterolemic effect of banana(Musa Sapientum L. var. Cavendishii)pulp in the rat fed on a cholesterol-containing diet Horigome,T.;Sakaguchi,E.;KishimotoC.
  11. 한국식품개발 연구원 연구보고서 지렁이에서 유용물질 추출에 관한 연구 이남형;박전홍;윤칠석;유근홍
  12. 한국인삼학회지 v.13 인삼사포닌 성분이 프로스타글란딘류 생성에 미치는 영향 이선희;박찬웅;이인란;한병훈
  13. 한국영양학회지 v.28 장기적인 인삼섭취가 인체의 혈전관련 요인에 미치는 영향 이정희;김숙희
  14. 한국영양식량학회지 v.21 no.2 고콜레스테롤혈증 유발 흰쥐에 있어서 버섯류가 지질성분에 미치는 영향 김군자;김한수;정승용
  15. 한국영양식량학회지 v.23 no.5 식용 버섯과 식물성 유지의 혼합급여가 흰쥐 간장의 지질성분 및 지방산 조성에 미치는 영향 김군자;김한수;김성희;김회숙;최운정;정승용
  16. J. Lipid Res. v.26 Reduction in plasma cholesterol and increase in biliary cholesterol by a diet rich in n-3 fatty acids in the rat Balasubramaniam,S.;Simons,L.A.;Chang,S.;Hickie,J.B.
  17. Am. J. Clin. Nutr. v.42 Effect of dietary cholesterol and degree of fat unsaturation on plasma lipid levels, lipoprotein composition, and fecal steroid excretion in normal young adult men Oh,S.Y.;Monaco,P.A.
  18. Preventive Med. v.4 Reduction in blood pressure associated with high polyunsaturated fat diets that reduce blood cholesterol in man Iacono,J.M.;Marshall,M.W.;Dougherty,R.M.;Wheeler,M.A.
  19. Am. J. Clin. Nutr. v.37 Effects of saturated, monounsaturated and w-6 polyunsaturated fatty acids on plasma lipids, lipoproteins, and apoproteins in human Becker,N.;Illingworth,D.R.;Alauporic,P.;Connor,W.E.;Sundberg,E.E.
  20. New Eng. J. Med. v.312 Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia Phillipson,B.E.;Rothrock,D.W.;Connorm,W.E.;Harris,W.S.;Illingworth,D.R.
  21. Clin. Exp. Hypertension v.3 Effect of polyunsaturate-rich vegetable oils on blood pressure in essential hypertension Rao,R.H.;Rao,U.B.;Srikantia,S.G.
  22. Jap. Circ. J. v.27 Development of a strain spontaneously hypertensive rats Okamoto,K.;Aoki,K.
  23. Clin. Chem. v.18 Estimation of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Friedewald,W.T.;Levy,R.I.;Fredrickson,D.S.
  24. 일본약리학회지 v.86 콜레스테롤 負荷SHR에 미치는 Nicardipine의 영향 大庭忠弘;展岡まゆみ;三島育夫;中山貞男;安原一;坂本浩二
  25. 한국영양식량학회지 v.18 어유식이가 본태성 고혈압쥐(SHR) 혈압 및 지질 대사에 미치는 영향 신응남;배복선;이원정;조성희
  26. 한국지질학회지 v.1 고혈압과 정상혈압쥐에서의 식이지방 변화에 따른 혈청과 간의 지질대사 동향 조성희;신응남;서미영
  27. Lipids v.24 Effect of essential fatty acid depletion on tissue phospholipid fatty acids in spontaneously hypertensive and normotentive rats Huang,Y.S.;Mills,D.E.;Ward,R.P.;Horrobin,D.F.;Simmons,V.A.
  28. Endorinology v.108 INhibition of the pathogenesis spontaneously hypertensive rat by feeding a high fat diet Wexler,B.C.
  29. Nippon Shokuhin Kogyo Gakkaishi v.36 Enzymatic degradation of rutin in processing of buckwheat noodles Ohara,T.;Ohinata,H.;Muramatsu,N.;Oike,T.;Matsuhashi,T.
  30. 현대생약학 한덕룔(외 12인 공저)
  31. 東京醫學學會雜誌 v.28 酒井和太郞
  32. 한국균학회지 v.15 고등균류의 한방적 이용 안덕균
  33. AOCS Annual Meeting, St. Louis, Missouri The evidence for the antiatherogenicity of high density lipoprotein in man Miller,N.E.
  34. J. Lipid Res. v.33 Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate Wooller,L.A.;Spady,D.K.;Dietschy,J.M.
  35. J. Lipid. Res. v.34 Effect of dietary n-3 versus n-6 polyunsaturrated fatty acids on hepatic excretion of cholesterol in the hamster Burr,F.;Goetz,A.;Schreiber,E.;Paumgartner,G.
  36. J. Nutr. v.119 The interrelated effects of n-3/n-6 and polyunsaterated/saturated ratios of dietary fats on the regulation of lipid metabolism in rats Lee,J.H.;Fukumoto,M.;Nishima,H.;Ikeda,I.;Sugano,M.
  37. Am. J. Clin. Nutr. v.53 Lowering of HDL2-cholesterol and lipoprotein A-1 particle levels by increasing the ratio of polyunsaturated to saturated fatty acids Fumeron,F.;Brigant,L.;Parra,H.J.;Bard,J.M.;Fruchart,J.C.;Apfelbaum,M.
  38. J. Lipid. Res. v.26 Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and pipoproteins in man Mattson,F.H.;Grundy,S.M.
  39. Am. J. Clin. Nutr. v.42 Why do polyunsaturated fatty acids lower serum cholesterol? Beynen,A.C.;Katan,M.B.
  40. 한국영양식량학회지 v.23 no.1 아마인유와 해바라기 종자유의 혼합 급여가 식이성 고지혈증 흰쥐의 혈청지질 성분에 미치는 영향 최은정;김한수;강정옥;김성희;서인숙;정승용
  41. Am. Heart. J. v.119 Modification of experimental and clinical atherosclerosis by dietary fish oil Zhu,B.Q.;Parmley,W.W.
  42. Nutr. Res. v.14 A study of plasma and liver lipid profile of rats fed palm oil or safflower oil along with cholesterol Purushothama,S.;Nardsimhamurhy,K.;Raina,P.L.;Hariharan,K.
  43. J. Lipid Res. v.35 Dietary fish oil potentiates bile acid-induced cholesterol secretion into bile in rats Smit,M.J.;Verkade,H.J.;Havinga,R.;Vonk,R.J.;Scherphof,G.L.;In't Veld,G.;Kuipers,F.
  44. Am. J. Clin. Nutr. v.51 The effect of diets high in buffer, corn oil, or high-oleic sunflower oil on serum lipids and apolipoproteins in men Wardlaw,G.M.;Snook,J.T.
  45. Lancet. v.1 no.8335 Hyper-response to dietary cholesterol in man(letter) Katan,M.B.;Beynen,A.C.
  46. Arch. Intern. Med. v.148 Report of the national cholesterol program expert panel on detection, evaluation and treatment of high blood cholesterol in adults Goodman,D.S.
  47. Circulation v.82 An analysis of randomized trials evaluating the effect of cholesterol reduction on total mortality and coronary heart disease incidence Holme,I.
  48. J. Am. Med. Assoc. v.257 Beneficial effects of combined colestipol-niacin therapy on coronary venous bypass grafts Blankenhorn,D.H.;Nessim,S.A.;Johnson,R.L.;Sanmarco,M.E.;Azen,S.P.;Cashin-Hemphill,L.
  49. Am. J. Clin. Nutr. v.24 Effect of dietary egg on variability of plasma cholesterol levels and lipoprotein cholesterol Oh,S.Y.;Miller,L.T.
  50. Korean J. Lipidology v.1 Hypercholesterolemia in Korea and nutritional factors Lee,Y.C.