Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
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Surgical Results for Myasthenia Gravis

중증근무력증의 수술적 치료 결과

  • 장인석 (경상대학교 의과대학 흉부외과학교실) ;
  • 김성호 (경상대학교 의과대학 흉부외과학교실)
  • Published : 1997.01.01
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Abstract

Myasthenia gravis is relatively rare disease which is related autoimmune response. There are various methods of management for myasthenia gravis, but nowaday radical thymectomy is the treatment of choice in the aspect of bringing out complete remission and clinical improvement. Sixteen patients of myasthenia gratis underwent radical thymectomy during last eight years, and its result was analysed. Complete rem ssion was achieved in five patients (31 %) and pharmacological or symptomatic improvement in seven patients (44%), thus giving a total remission in 12 patients (75%). Postoperative result was not correlated with age, sex, degree of preoperative symptom, surgical approach, pathologic diagnosis.

중증 근무력증은 자가면역 반응에 의해 유발되는 비교적 드문 질환으로, 여러 가지의 치료 방법이 시행되고 있으나 현재는 완전 관해와 증상의 호전이 탁월하다는 점에서 광범위 흉선 절제술을 주된 치료의 방법으로 선택하고 있다. 본원에서는 지난 8년간 16명의 중증 근무력증 환자에 대해 흉선 절제술을 시행하여 결과를 분석하였다. 5례(31%)에서 완전 관해가 보였으며, 7례(44%)에서는 약 투여량의 감소 또는 증상의 호전을 보여 총75%에서 수술적 호전을 보았다 환자의 나이, 성별, 술전 증상의 정도, 수술적 접근 방법 및 조직학적인 결과 등을 분석하였으나 수술 후 예후와는 통계적 상관관계는 보이지 않았다.

Keywords

References

  1. Eur Neurol v.34 Myasthenia gravis associated with thymoma : clinical characteristics and long-term outcome. Palmisani MT;Evoli A;Batocchi AP;Provenzano C;Tonali P
  2. Lancet v.25 no.ⅱ Remission ofmyasthenia gravis following plasma exchange Pinching AJ;Peter DK;Newsom-Davis J
  3. N Eng Med v.298 Myasthenia gravis Drachman DB
  4. 대흉외지 v.23 중증근무력증의 외과적 요법 -25례 보고-. 서필원;성숙환;김주현
  5. 대흉외지 v.25 중증근무력증의 광범위흉선절제술 조광조;이형렬;김원종;정황규;성시찬
  6. Surgery v.112 Management of myasthenia gravis by extended thymectomy with anterior mediastinal dissection Nussbaum MS;Rosenthal GJ;Samaha FJ(et al.)
  7. J Surg Oncol v.50 Effects of surgical treatment in thymoma with myasthenia gravis : our experience in 103 patients Crucitti F;Doglietto GB;Bellantone R;Perri V;Tommasini O;Tonali P
  8. Cancer v.48 Follow-up study of thymoma with special reference to their clinical stages Masaoka A;Monden Y;Nakahara K;Tanioka T
  9. J Child Neurol v.8 Tests for juvenile myasthenia gravis : comparative diagnostic yield and prediction of outcome Afifi AK;Bell WE
  10. Scot Med J v.5 Myasthenia gravis. A new hypothesis Simpson JA
  11. Brit Med J v.283 Pathogenesis and treatment of myasthenia gravis Scadding GK;Havard CWH
  12. Ann Surg v.110 Myasthenia gravis and tumor of the thymic region Blalock A;Mqason MF;Morgan HJ;Riven SS
  13. Ann Thorac Surg v.57 Transcrvical thymectomy for myasthenia gravis DeFilippi VJ;Richman DP;Ferguson MK
  14. Eur J Cardiothorac Surg v.9 Maximal thymectomy for myasthenia gravis Ashour MH;Jain Sk;Kattan KM(et al.)
  15. J Thorac Cardiovasc Surg v.109 Prevalence of ectopic thymic tissue in myasthenia gravis and its clinical significance Ashour M
  16. Ann Thorac Surg v.57 Thymectomy for the myasthenia gravis patient : factors influencing outcome Frist WH;Thirumalai S;Doehring CB(et al.)
  17. Arch Surg v.128 Thymectomy for myasthenia gravis Blossom GB;Ernstoff RM;Howells GA;Bendick PJ;Glover JL
  18. 대흉외지 v.27 중증 근무력증의 외과적 치료 이광선;장기경;임승현;김 훈;한영숙
  19. Acta Neurol Napoli v.15 Thymectomy for myasthenia gravis : predictive factors and long term evolution. A retrospective study on 46 patients Marano E;Pagano G;Persico G;Striano S;Buscaino GA;Campanella G