Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effect of Artemisia Princeps var Orientalis and Circium Japonicum var Ussuriense on Cardivascula System of Hyperlipidemic Rat

쑥 및 엉정퀴가 식이성 고지혈증 흰쥐의 심혈관계에 미치는 영향

  • 임상선 (경상대학교 식품영양학과)
  • Published : 1997.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

The effects of Artemisia princeps var orientalis(mugwort), Circium japonicum var ussuriense (Unggungqui) on cadiovascular system in hyperlipidemic rats were investgated. Thirty rats devided into 5 experimental groups, were fed with the diet contained 1% chlesterol, 0.25% sodium cholate, 10% coconut oil and 5% lard by the same method of previous paper1). Contractile and relaxation responses in the isolated artria and thoracic aortae were measured and the morphological changes of the aortic endotherium from the rats were inspected. The responses of the right atrial to isoproterenol were significantly lower value in Ungungqui powder diet group(UP) and mugwort powder diet group(MP) than the control. The contraction force by injectin of phenylephrine and calcium in isolated thoracic aortae was significantly low value in the UP and the MP groups compaired to the control. The relaxation rate by acetylcholine in isolated thoracic aortae represented significantly higher value in UP than control. The morphological changes of endothelial cell suface was smallest in UP and the damage of endothelium by retarded in MP. Although Ungungqui and mugwort extract diet groups(UE, ME) were advanced, those were less than control.

Keywords

References

  1. 한국영양학회지 v.30 no.1 쑥 및 엉겅퀴가 식이성 고지혈증 흰쥐의 혈청지질에 미치는 영향 임상선;이종호
  2. Pro Natl Acad Sci USA v.77 Malondialdehyde alteration of LDL leads to cholesterol ester accumulation in human monocyte and macrophage Fogelman,A.M.;Schechter,T.;Seager,J.;Hokem,M.;Child,J.S.;Edwards,P.A.
  3. J Exp Med v.35 Effect of cholesterol diet on aorta of hypertensive rats(SHRSP)-ultrastructural study Kishino,Y.;Yoshioka,A.;Wakitani,C.
  4. Br Med J v.289 Lipid peroxides and atherosclerosis Stringer,M.D.;Gorog,P.G.;Freeman,A.;Kakker,V.V.
  5. Arteriosclerosis and Thrombosis v.13 Decreased basal nitric oxide release in hypercholesterolemia increased neutrophill adherence to rabbit coronary artery endothelium Lefer,A.M.;Ma,X.L.
  6. Science v.221 Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets Cohen,R.A.;Shepherd,J.T.;Vanhoutte,P.M.
  7. Chest v.78 $Ca^{2+}$ movements in smooth muscle Van-Breemen,C.;Aaronson,P.;Loutzenhier,P.R.;Meisheri K.
  8. J Clin Invest v.86 Impaired vasodilation of forearm resistance ressels in hypercholesterolemic humans Creager,M.A.;Cooke,J.P.;Mendelsohn,M.E.;Gallagher,S.J.;Coleman,S.M.;Loscalzo,J.;Dzau,V.J.
  9. Can J Physiol Pharmacol v.67 Persistent impairment of endothelium dependent relaxation to acetylcholin and progression of atherosclerosis following 6 weeks of cholesterol feeding in the rabbit Jayakody,L.;Senaratne,M.P.J.;Thomson,A.B.R.;Sreeharan,N.;Kappagoda,C.T.
  10. Circulation v.85 Atherosclerosis of lipoprotein induced endothelial dysfunction Flavahan,N.A.
  11. J Clin Invest v.66 Supersensitivity of atherosclerotic rabbit aorta to ergonovine Henry,P.D.;Yokoyama,M.
  12. Chem Pharm Bull v.33 no.5 Studies on the activities of tannis and related compounds from medicinal plants and drug. Ⅶ. Effects of extracts of leaves of Artemisia, Species and caffeic acid and chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil Kimura,Y.;Okuda,H.;Okuda,T.;Hatano,T.;Agata,I.;Arichi,S.
  13. 104th Annual meeting of the Pharmaceutical society of Japan Abstracts of paper Okuda,T.;Hatano,T.;Katayama,M.;Agata,I.;Nishibe,S.;Kimura,K.
  14. 한국영양식량학회지 v.21 no.1 쑥(산쑥)의 물 抽出物과 에테르 抽出物의 抗酸化 效果 이기동;김정숙;배재오;윤형식
  15. Circulation v.71 Associations of resting heart rate with concentrations of lipoprotein subfractions in sedentary men Williams,P.T.;Haskell,W.L.;Vranizan,K.M.;Blair,S.N.;Krauss,R.M.;Superko,H.R.;Albers,J.J.;Frey-Hewitt,B.;Wood,P.D.
  16. Circulation v.86 Association between heart rate and atherogenic blood lipid fractions in a population Bφnaa,K.H.;Arnesen,E.
  17. Cir Res v.56 Differences in norepinephrine activation and diltiazem inhibition of $Ca^{++}$ channels in isolated rabbit aorta and messenteric resistance vessels Cauvin,C.;Lukeman,S.;Cameron,J.;Hwang,O.;Van Breemen,C.
  18. Cir Res v.45 Sensitization of isolated canine coronary arteries to calcium ions after exposure to cholesterol Yokoyama,M.;Henry,P.D.
  19. J Pharmacol Exp Ther v.259 Inhibition of binding of [³H] PN 200-110 to membranes from rat brain and heart by ascorbate is mediated by lipid peroxidation Ebersole,B.J.;Mdinoff,P.B.
  20. Br J pharmacol v.81 Enhanced responsiveness of rat isolate aorta to clonidine after removal of the endothelial cells Egleme,C.;Godfraind,T.;Miller,R.C.
  21. Cir Res v.58 Effect of hypercholesterolemia on vascular reactivity in the rabbit Verbeuren,T.J.;Jordaens,F.H.;Zonnekeyn,L.L.;Van Hove,C.E.;Coene,M.C.;Herman,A.C.
  22. Circulation v.80 Endothelium-derived relaxing factor and coronary vasospasm Vanhoutte,P.M.;Shimokawa,H.
  23. Arteriosclerosis and Thrombosis v.13 Hypercholesterolemia is associated with a reduced response of smooth muscle guanylyl cyclase to nitrovasodilater Schmidt,K.;Klatt,P.;Mayer,B.
  24. Nature v.327 Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta Andrews,H.E.;Bruckdorfer,K.R.;Dunn,R.C.;Jacobs,M.
  25. JAMA v.264 Lipoproteins and atherogenesis Steinberg,D.;Witztum,J.L.
  26. Arteriosclerosis and Thrombosis v.12 Superoxide dependent stimulation of leukocyte adhesion by oxidatively modified LDL in vivo Lehr,H.A.;Becker,M.;Marklund,S.L.;Hubner,C.;Arfors,K.E.;Kohschutter,A.;Messmer,K.
  27. Circulation v.85 Autioxidants in the Prevention of Human Aterosclerosis Steinberg,D.
  28. Pharmacological Research v.23 Endothelial altherations in hypercholesterolemia and altherosclerosis Lefer,A.M.;Sedar,A.W.
  29. N Engl J Med v.314 The pathogenesis of atherosclerosis an update Ross,R.
  30. Arteriosclerosis and Thrombosis v.12 Aortic permeability to LDL as a predictor of aortic cholesterol accumulation in cholesterol-fed rabbits Nielsen,L.B.;Nordestgaard,B.G.;Stender,S.;Kjelosen,K.
  31. Atherosclerosis v.51 Injury of arterial endothelial cells in diabetic sucrose fed and aged rats Arbogast,B.W.;Berry,D.L.;Newell,C.L.
  32. Diabets v.31 In vitro injury of porcine aortic endothelial cells by very low density lipoproteins from diabetic rats serum Arbogast,B.W.;Berry,D.L.;Raymond,N.
  33. Biochem Biophys Acta v.618 Abnormal effects of hypertriacyl glycerolemic very low-density lipoproteins on 3-hydroxy-3-methylglutary-CoA reductase activity and viability of cultured bovine aortic endothelial cell Gianturco,S.H.;Eskin,S.G.;Navarro,L.T.;Lahart,C.T.;Smith,L.C.;Gotto,M.
  34. 한국식품영양과학회지 엉겅퀴 지상부의 심혈관 작용활성 및 후라본 배당체의 분리 임상선;이종호;박종철
  35. 한국영양학회지 쑥 수용성 추출물의 심혈관 및 혈압에 대한 활성연구 임상선;이종호
  36. Chem Pharm Bull v.38 A stimulatory effect of artemisia leaf extract on proliferation of cultured endothelial cells Kaji,T.;Kaga,K.;Miezi,N.;Sakuragawa,N.
  37. 약학회지 v.28 no.2 애엽(艾葉)의 血液 凝固 抑制成分에 관한 硏究 韓龍男;梁賢玉;韓秉勳