Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지

Neuronal Cell Protection Activity of Macrolactin A Produced by Actinomadura sp.

  • Kim, Hyeon-Ho (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Won-Gon (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Ryoo, In-Ja (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Chang-Jin (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Suk, Jae-Eun (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Han, Kyou-Hoon (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Hwang, Se-Young (Graduate School of Biotechnology, Korea University) ;
  • Yoo, Ick-Dong (Korea Research Institute of Bioscience and Biotechnology, KIST)
  • Published : 1997.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Macrolactin A, 24-membered macrolide, was isolated from the culture broth of Actinomadura sp. as a neuronal cell protecting substance. In the cell assay, this compound inhibited glutamate toxicity in N18-RE-105 cells with an $EC_50$ value of 0.5 ${\mu}g/ml.

Keywords