YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Crystal Modification of Cephalothin Sodium on Dissolution and Stability

세파로틴 나트륨의 결정형이 용출과 안정성에 미치는 영향

  • 손영택 (덕성여자대학교 약학대학) ;
  • 박선희 (덕성여자대학교 약학대학)
  • Published : 1997.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Investigation of polymorphism has become a requirement in the pharmaceutical industry because the physical properties and bioavailabilities of crystalline drugs depend on their polymorphic form. Five polymorphic modifications and one pseudopolymorphic modification of ecphalothin sodium were prepared by recrystallization, and characterized by UV spectrophotometer, DSC, TGA and X-ray crystallography. The solubilities of all modifications were examined by the disslution test. Form 2 and 1 showed higher solubilities than any other crystal forms. The modifications were also investigated for their stability after storage of 2 months at 100%, 76%, 52% and 0% humidity.

Keywords

References

  1. J. Pharm. Sci. v.52 Dissolution behavior of crystalline solvated and nonsolvated forms of some pharmaceuticals Shefter, E.;Higuchi, T.
  2. J. Pharm. Sci. v.54 Development of in vitro dissolution tests with correlate quantitatively with dissolution rate limited absorption Levy, G.;Leonards, J. R.;Procknal, J. A.
  3. J. Pharm. Sci. v.58 Pharmaceutical applications of polymorphism Haleblian, J. K.;McCrone, W.
  4. J. Pharm. Sci. v.64 Characterization of habits and crystalline modification of solids and pharmaceutical application Haleblian, J. K.
  5. Pharmacon v.21 Pharmaceutical applications of polymorphism Sohn Y. T.
  6. Int. J. Pharm. v.59 Dehydration effect on the stability of cefixime trihydrate Kitamura, S.;Koda, S.;Miy amae, A.;Yasuda, T.;Morimota, Y.
  7. Pharm. Acta Helv. v.56 Polymorphisme des butyrophenones: la butropipazone Azibi, M.;Draguet-Brughmans, M.;Bouche, R.
  8. J. Kor. Pharm. Sci. v.20 Study on the Polymorphism of sulfa drugs Sohn Y. T.
  9. J. Pharm. Sci. v.67 Quantitative Crystallinity Determinations for β-Lactam Antibiotics by Solution Calorimetry: Correlations with Stability Pikal, M. J.;Lukes, A. L.;Lang, J. E.;Gaines, K.
  10. Chem. Pharm. Bull. v.39 Physicochemical properties of nitrofurantoin anhydrate and monohydrate and their dissolution Otsuka. M.;Teraoka, R.;Matsuda, Y.
  11. J. Pharm. Sci. v.57 Dissolution behavior and solubility of anhydrous and trihydrate forms of ampicillin Poole, J. W.;Bahal, C. K.
  12. J. Kor. Pharm. Sci. v.23 Study on polymorphism of cimetidine Sohn, Y. T.;Kim, K. S.
  13. Yakhak Hoeji v.39 The effects of pseudopolymorphism on the relative bioavailability of amoxicillin Sohn, Y. T.
  14. Yakhak Hoeji v.40 Crystal forms of cefazolin sodium hydrates Sohn, Y. T.;Lee, E. H.