Yomogin, an Inhibitor of Nitric Oxide Production in LPS-Activated Macrophages

Abstract

In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plant Artemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.

Keywords

• Yomogin;
• Artemisia princeps;
• Nitric oxide;
• Nitric oxide synthase;
• Induction;
• LPS;
• Inhibitor