YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Isolation of Inhibitory Components on Tyrosinase Activity from the Bark of Paeonia moutan

목단피로부터 멜라닌 생성 억제성분의 분리

  • Published : 1998.08.01
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Abstract

The MeOH extract of the bark of Paeonia moutan showed potent inhibitory effect on the mushroom tyrosinase activity in vitro. The activity-guided fractionation of t he MeOH extract resulted in the isolation of three active compounds. The chemical structures of these compounds were elucidated by chemical and spectroscopic evidence as catechin, 1,2,3,6-tetra-O-galloyl-${\beta}$-D-glucose and 1,2,3,4,6-penta-0-galloyl-${\beta}$-D-glucose, respectively. Among them, the inhibitory activity by 1,2,3,6-tetra-galloyl-${\beta}$-D-glucose on mushroom tyrosinase was more potent $(IC_{50}=3.5\;{\mu}M)$ than that of kojic acid $(IC_{50}=8.7\;{\mu}M)$ ,but catechin enhanced the mushroom tyrosinase activity 50% in the concentration of 34.5M.

Keywords

References

  1. Fragrance Journal v.1990 no.6 最新のメラ二ン制御劑と美白化粧品の開發 小磯一郞
  2. Fragrance Journal v.1990 no.6 メラ二ン色素生成のメ力二ズムとその制御 三島豊;芝田孝一
  3. J. Invest. Dermatol. v.75 Recent advances in the chemistry of melanogenesis in mammals Prota G.
  4. Cancer Detection and Prevention v.6 Eumelanin(precursor) metabolites as markets for pigmented malignant melanoma, a preliminary report Pavel S.;Muskiet F. A.
  5. 약학회지 v.41 no.4 고등식물로 부터 피부멜라닌 생성에 관여 하는 티로시나제 활성 억제물질의 탐색 이승호;박지수;김소영;김진준;정시련
  6. Natural Product Sciences v.3 no.2 Inhibitory effects of herbal extracts on DOPA oxidase activity of tyrosinase Shin N.;Lee K. S.;Kang S.;Min K. R.;Lee S. H.;Kim Y.
  7. 현대생약학 생약학연구회
  8. 藥學雜誌 v.105 no.1 Studies on Moutan Cortex Ⅸ Kubo M.;Nagao T.;Matsuda H.;Tani T.;Arichi S.;Kitagawa I.
  9. 東洋傳統藥物原色圖鑑 金在吉;肖培根
  10. J. Biol. Chem. v.261 no.35 Tyrosinase isozyme heterogeneity in differentiating B-16/C3 melanoma Laskin J. D.;Piccinini L. A.
  11. J. Chem. Soc. Perkin Trans. v.Ⅰ Synthesis and conformation of procyanidin diastereoisomers Foo L. Y.;Porter L. J.
  12. J. Chem. Soc. Perkin Trans. v.Ⅰ The metabolism of gallic acid and hexahydroxydiphenic acid in plants Haddock E. A.;Gupta R. K.;Al-Shafi M. K.;Haslam E.;Magnolata D.
  13. Chem. Pharm. Bull. v.35 no.8 Tannins and related compounds LVⅢ. Novel gallotannins possessing α-glucose core from Nuphar japonicum, Nonaka G. I.;Ishimatsu M.;Tanaka T.;Nishioka I.;Nishizawa M.;Yamagishi T.
  14. Fragrance Journal v.90 no.6 生藥の機能と美白效果 池田孝夫;堤龍彦
  15. Proceeding of International Symposium of Natural Products The tyrosinase inhibitory components from Artocarpus incisus Shimizu K.;Kondo R.;Sakai K.;Sato H.
  16. Biol. Pharm. Bull. v.17 no.2 Tyrosinase inhibitors from crude drugs Shibata S.;Miyazaki K.;Aiyama R.;Ichioka M.
  17. Biosci. Biotech. Biochem. v.56 no.10 Tyrosinase inhibitors from Albatrellus confluens Misasa H.;Matsui H.;Uehara H.;Tanaka H.;Ishihara M.;Shibata H.