Effect of Bifidobacterium longum HY8001 Administration on Human Fecal Bacterial Enzymes and Microflora

Bifidobacterium longum HY8001의 섭취가 사람의 장내세균층 및 장내세균 효소에 미치는 영향

  • 이완규 (충북대학교 수의과대학) ;
  • 이상명 (충북대학교 수의과대학) ;
  • 배형석 ((주)한국야쿠르트 중앙연구소) ;
  • 백영진 ((주)한국야쿠르트 중앙연구소)
  • Published : 1999.08.01

Abstract

The effects of Bifidobacterium longum HY8001 supplement intake on the fecal microflora and fecal bacterial enzyme activity were studied in ten healthy human volunteers, before, during and after intake (respectively for 3 weeks). During intake of B. longum HY8001 supplement, fecal, $\beta$-glucuronidase and nitroreductase activities significantly decreased 44.6%(p<0.005) and 32.3%(p<0.01), respectively. Although numbers of major bacterial groups of fecal microflora were not affected by B. longum HY8001 intake for 3 weeks, the number of Bifidobacterium was significantly increased (p<0.05). This result indicates that intake of B. longum HY8001 might be potentially beneficial for the prevention and inhibition of colon cancer and improvement of human intestinal microflora composition.

Keywords

References

  1. Int. J. Cancer v.15 Environmental factors of cancer incidence and mortality in different countries with special reference to dietary factors Amstrong, B.;R. Doll
  2. Microbiol. Immunol. v.36 Impact of Bifidobacterium longum on human fecal microflora Benno, Y.;T. Mitsuoka
  3. Acta Chir. Scand v.S 2562 Human fecal flora in health and colon cancer Benno, Y.;T. Mitsuoka;K. Kanazawa
  4. Prog. Clin. Biol. Res. v.181 Metabolism of 1-nitropyrene and 6-nitrobenzo[α]pyrene by intestinal microflora Cerniglia, C. E.
  5. J. Clin. Nutr. v.25 Intestinal bacteria and cancer Drasar, B. S.
  6. Am. J. Clin. Nutr. v.27 Effect of diet on human fecal flora: Comparison of Japanese and American diets Finegold, S. M.;H. R. Attebery;V. L. Sutter
  7. Bifidobact. Microfl. v.11 β-Glucuronidase activity of Escherichia coli isolated over a long term from feces of the same human Fujisawa, T.;M. Mori
  8. Cancer v.40 Alterations in faecal microflora enzymes related to diet, age, Lactobacillus supplements and DMH Goldin B. R.;S. L. Gorbach
  9. J. Natl. Cancer Inst. v.64 Effect of Lactobacillus acidophilus supplements on 1, 2-dimethylhydrazine dihydrochloride induced intestinal cancer in rats Goldin, B. R.;S. L. Gorbach
  10. Am. J. Clin. Nutr. v.39 The effect of milk and Lactobacillus feeding on human intestinal bacterial enzyme activity Goldin, B. R.;S. L. Gorbach
  11. Inflammatory Bowel Disease Intestinal microflora in inflammatory bowel disease-implications for etiology and therapy Gorbach, S. L.;J. B. Krisner(ed.);R. G. Shorter(ed.)
  12. Appl. Env. Microbiol. v.49 β-Glucuronidase activities of intestinal bacteria determined both in vitro and in vivo in gnotobiotic rats Gradclle, D.;P. Raib;E. Saquent
  13. Cancer v.70 Colon cancer overview Greenwald, P.
  14. Cancer v.36 The role of colon anaerobes in the metabolism of bile acids and steroids, and its relation to colon cancer Hill, M. J.
  15. Lancet v.1 Bacteria and etiology of cancer of the large bowel Hill, M. J.;B. S. Drasar;V. Aries;J. S. Crowther;G. Hawk-sworth;R. E. O. Williams
  16. Kor. J. Dairy Sci. v.11 Studies on the occurrence of Bifidobacterium in Korea Huh, C. S.;S. W. Lee;K. B. Yoon
  17. Lancet v.2 Dietary fiber, transit time, fecal bacteria, steroids and colon cancer in two Scandinavian populations IARC
  18. Lab. Anim. v.25 Isolation and identification of clostridia from the intestine of laboratory animals Lee, W. K.
  19. J. Biol. Chem. v.193 Protein measurements with Folin phenol reagent Lowry, O. H.;J. J. Rosebrough;A. L. Farr;R. L. Ran-dall
  20. Microbial Ecol. in Health and Dis. v.1 Effect of dietary supplements of apple pectin, wheat bran or fat on the enzyme activity of the human fecal flora Mallet, A. K.;I. R. Rowland;C. A. Bearne;J. C. Flynn;B. J. Fehilly;Y. S. Udeen;M. J. G. Farthing
  21. The World of Anaerobic Bacteria; A color Atlas of Anaerobic Bacteria Mitsuoka, T.
  22. Jap. J. Microbiol. v.13 A simple method(" platc-in-bottle method ") for the cultivation of fastidious anaerobes Mitsuoka, T.;Y. Morishita;A. Terada
  23. Appl. Environ. Microbiol. v.59 no.6 Comparison of the azore-ductase and nitroreductase from Clostridium perfringens Raffi, F.;C. E. Cerniglia
  24. Appl. Environ. Microbiol. v.57 no.4 Reduction of nitroaromatic compounds by anaerobic bacteria isolated from the human gastrointestinal tract Raffi, F.;W. Faranklin;R. H. Helflich;C. E. Cerniglia
  25. Crit. Rev. Fd. Sci. Nutr. v.35 Nutritional factors and colon cancer(review) Reddy, B. S.
  26. J. Nutr. v.110 Effect of high fat high beef diet on fecal bacterial enzymes and fecal bile acids and neutral sterols Reddy, B. S.;D. Hanson;S. Mangat;L. Mathews;M. Sbaschning;C. Sharma;B. Simi
  27. Food Chem. Toxicol. v.21 Metabolic profile of caecal microorganism from rats fed indigestible plant cell-wall components Rowland, I. R.;A. Wise;A. K. Mallett
  28. Microbial Ecol. in Health and Dis. v.5 Effect of soybean oligosaccarides on the human gut microflora in vitro culture Saito, Y.;T. Takano;I. R. Rowland
  29. Environ. Health Perspect v.73 The nature of the mutagenicity and carcinogenicity of nitrated aromatic compounds in the environment Tokiwa, H.;R. Nakagawa;K. Horikawa;A. Ohkubo