Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effects of Taurine and $\beta$-alanine on Blood Glucose and Blood Lipid Concentrations in Streptozotocin-induced Diabetic Rats

타우린과 베타알라닌이 실험적 당뇨유발 쥐의 혈당 및 혈정지질농도에 미치는 영향

  • 장경자 (인하대학교 생활과학대학 식품영양학과)
  • Published : 1999.04.01
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Abstract

The purpose of this study was to determine the dose effects of taurine supplementation and effects of taurine depletion in diabetic rats. Sprague-Dawley male rats were fed the purified diets and supplemented with 1, 2 or 3% taurine in drinking water for 7 weeks(E1, E2 and E3, respectively). To induce taurine depletion, rats were treated with 5% $\beta$-alanine in drinkeng water (EA). Diabetes was induced by streptozotocin injection(50mg/kg B.W) after 3 weeks. Taurine-depleted diabetic rats(EA)had significantly lower body weight compared to those of nondiabetic(CO), nontaurine-supplemented diabetic(E0) and taurine-supplemented diabetic rats(E1, E2 and E3). E0 had significantly higher food intake compared to that of CO and EA. E1, E2 and E3, however, had significantly lower food intake compared to that of E0, and E3 had significantly lower food intake compared to that of E1 and E2. E0 had significantly higher water intake compare to that of CO and EA. EI had significantly lower water intake compared to that of E0. Blood glucose concentration of E0 was significantly increased compared to that of CO and EA. E2 and E3 had significantly lower blood glucose concentration compared to E0 and E1. Also there was a dose effect in blood glucose concentration between E2 and E3. The total cholesterol and LDL-cholesterol concentrations of EA were significantly increased compared to those of other groups. Therefore, it may be suggested that taurine supplementation is necessary for diabetes in order to prevent diabetic complications such as cardiac vascular diseases.

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