Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antiatherogenic Effect of the Extract of Allium victorialis on the Experimental Atherosclerosis in the Rabbit and Transgenic Mouse

동맥경화유발 토끼와 형질전환 마우스에서 산마늘 추출물의 항동맥경화 효과

  • Kim, Tae-Gyun (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim, Seung-Hee (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kang, Soeg-Youn (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jung, Ki-Kyung (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Choi, Don-Ha (Lab. of Natural Products Chemistry, Forestry Research Institute) ;
  • Park, Yong-Bok (Department of Genetic Engineering, Kyungpook National University) ;
  • Ryu, Jong-Hoon (Department of Oriental Pharmaceutical Science, Kyung-Hee University) ;
  • Han, Hyung-Mee (National Institute of Toxicological Research, Korea Food and Drug Administration)
  • 김태균 (식품의약품안전청 국립독성연구소) ;
  • 김승희 (식품의약품안전청 국립독성연구소) ;
  • 강석연 (식품의약품안전청 국립독성연구소) ;
  • 정기경 (식품의약품안전청 국립독성연구소) ;
  • 최돈하 (임업연구소 천연물화학연구실) ;
  • 박용복 (경북대학교 유전공학과) ;
  • 류종훈 (경희대학교 한약학과) ;
  • 한형미 (식품의약품안전청 국립독성연구소)
  • Published : 2000.06.30
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Abstract

Atherosclerosis is emerging as one of the major causes of death in Korea as well as Western societies. In the present study; hypocholesterolemic and antiatherogenic effects of the ethanol extract of Allium victorialis Makino was investigated using the conventional rabbit and the cholesteryl ester transfer protein (CETP)-transgenic mouse model. Hypercholesterolemia was induced by feeding high cholesterol diet to the animals for 30 days and they were then fed with high cholesterol diet containing 0.5% of the A. victorialis extract for additional 30 (or 40) days. In the experiment using rabbits, treatment with the A. victorialis extract significantly decreased plasma total cholesterol, low density lipoprotein (LDL)-cholesterol, triglyceride levels and lipid peroxidation compared to those in the control group. Total cholesterol contents in the liver and the heart were also significantly decreased. Lipid staining of the aorta isolated from the rabbits showed that treatment with the A. victorialis extract decreased formation of atheromatous plaques on the intima of the aorta. In the experiment employing CETP transgenic mouse model, treatment with the A. victorialis extract decreased the levels of plasma total cholesterol and the tissue triglyceride levels in the heart. These results demonstrated that the ethanol extract of A. victorialis lowered serum cholesterol levels, tissue lipid contents and accumulation of cholesterol in the artery.

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