Abstract
The decoction of Polygoni mulriflori Radix was divided into several fractions by the methods of extraction using methanol, membrane-permeability and HPLC. And the effects of the fractions on the contents of blood lipid in hyper-cholesterol rats and those on a pancreatic lipase were examined. The results were: 1. The fraction, which was insoluble in methanol and also had molecular weight of above 10 kdal, significantly decreased the level of total and LDL-cholesterol in the blood of hyper-cholesterol rats. 2. The fraction, which had an effects on the lipid contents, also contained some materials which increased the contents of cholesterol and LDL-cholesterol. 3. The fraction, which had an effects on the lipid contents, also saliently inhibited the activity of pancreatic lipase. But it was not clear whether there was an association between the effect of decreasing the contents of blood liquid and that of inhibiting the activity of lipase.