Screening of Crude Drugs for Antioxidative Activity

생약추출물의 항산화 활성검색

  • Na, Min-Kyun (College of Pharmacy, Chungnam National University,Jakwang Research Institute, HanKookSinYak Co., Ltd.) ;
  • An, RenBo (College of Pharmacy, Chungnam National University,College of Pharmacy, Yanbian University) ;
  • Lee, Sang-Myung (Korea Research Institute of Bioscience and Biotechnology) ;
  • Hong, Nam-Doo (Jakwang Research Institute, HanKookSinYak Co., Ltd.) ;
  • Yoo, Jae-Kuk (College of Pharmacy, Chungnam National University,Jakwang Research Institute, HanKookSinYak Co., Ltd.) ;
  • Lee, Chan-Bok (Jakwang Research Institute, HanKookSinYak Co., Ltd.) ;
  • Kim, Jin-Pyo (Jakwang Research Institute, HanKookSinYak Co., Ltd.) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
  • 나민균 (충남대학교 약학대학,(주)한국신약 자광연구소) ;
  • 안인파 (충남대학교 약학대학,연변대학교 약학원) ;
  • 이상명 (한국생명공학연구원) ;
  • 홍남두 ((주)한국신약 자광연구소) ;
  • 유재국 (충남대학교 약학대학,(주)한국신약 자광연구소) ;
  • 이찬복 ((주)한국신약 자광연구소) ;
  • 김진표 ((주)한국신약 자광연구소) ;
  • 배기환 (충남대학교 약학대학)
  • Published : 2001.06.30

Abstract

Based on DPPH radical scavenging activity and lipid peroxidation inhibitory activity, the MeOH extracts of 139 crude drugs were screened in order to search for antioxidants. Among tested samples, the extracts from the seed of Nelumbo nucifera, the fruit of Terminalia chebula var. gangetia, the root of Salvia miltiorhiza, the fruit of Ziziphus jujuba var. innermis, the root bark of Paeonia moutan, the fruit of Rubus coreanus, the fruit of Zanthoxylum schinifolium, the lignum of Caesalpinia sappan, the leaf of Pinus densiflora, the rhizome of Alpinia officinarum, the fruit of Syzygium aromaticum, the ramulus and uncus of Uncaria rhynchophylla, the root bark of Lycium chinense, and the fruit of Alpinia katsumadai showed a relatively strong antioxidative activity. Furthermore, the BuOH fraction from the extract of N. nucifera showed a potent activity in each assay. The isolation of bioactive compounds has been carried out and will be reported in the next paper.

Keywords