Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Characterization of an $\alpha$-Glucosidase Inhibitor Produced by Streptomyces sp. CK-4416

  • Published : 2001.06.01
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Abstract

An $\alpha$-glucosidase inhibitor, CK-4416, was identified from the culture broth of Streptomyces sp. CK-4416. CK-4416, which had some specificity against intestinal disaccharidases, especially sucrase and matlase activities, was purified by adsorption and cationic ion exchange chromatographies. The molecular formula was determined to be $C_{37}H_{63}NO_{30}$ (MW 1001.31) by FAB-MS and NMR analyses. In vitro studies found CK-4416 to show a potent inhibitory activity against sucrase and maltase, but it had low inhibition against $\alpha$-amylase.

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