KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Effects of the Dietary Mixture of Isoflavone on Osteoporosis

이소플라본 조성물이 골다공증에 미치는 효과

  • 이동선 (아주대학교 공과대학 화학생물공학부) ;
  • 변상요 (아주대학교 공과대학 화학생물공학부)
  • Published : 2001.08.01
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Abstract

Inhibitory effects of isoflavone against osteoporosis were studied with ovaryectomized rats. The diet mixture A of calcium, vitamin D$_3$, and vitamin K$_1$ and an additional mixture B with isoflavone were fed for 7 months to ovaryectomized rats. The contents of deoxypyridinoline in the urine of rats fed with the mixture A and B decreased 9.0% and 29.5%, respectively. The trabecular bone areas of proximal tibias of ovaryectomized rats fed with the mixture A and B were measured and compared to the control. They increased 9.9% and 15.8%, respectively, that proved the inhibitory effect of isoflavone against osteoporosis.

동물실험을 통하여 이소플라본의 골다공증 억제 효과를 연구하였다. 난소절제된 흰쥐에 기본사료, 칼슘, 비타민D$_3$, 비타민K$_1$를 함유하는 조성물과 이소플라본을 추가한 조성물을 7개월간 투여한 후 기본사료만 투여한 대조군과 비교하였다. 골 흡수 지표로 deoxypyridinoline을 분석한 결과 칼슘 비타민 조성물 투여군의 경우 대조군과 비교하여 9.0%, 이소플라본 추가 조성물 투여군의 경우 29.5% 감소하였다. 경골의 trabecular 골면적을 측정한 결과 칼슘 비타민 조성물 투여군의 경우 대조군과 비교하여 9.0%, 이소플라본 추가 조성물 투여군의 경우 15.8% 증가하여 이소플라본의 골다공증 억제 효과를 확인할 수 있었다.

Keywords

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