Protective Effect of an Aged Garlic-bamboo Salt Mixture on the Rat with the Alcohol-salicylate Induced Gastropathy

마늘-죽염 제제가 위장 장애 유발 흰쥐의 항산화 효소활성에 미치는 영향

  • Huh, Keun (College of Pharmacy, Yeungnam University) ;
  • Kim, Young-Hee (Insan Institute of Biotechnology, Insanga Inc.) ;
  • Jin, Da-Qing (College of Pharmacy, Yeungnam University)
  • 허근 (영남대학교 약학대학 약리학연구실) ;
  • 김영희 ((주)인산가 부설 인산 생명 과학 연구소) ;
  • 김대경 (영남대학교 약학대학 약리학연구실)
  • Published : 2001.06.01

Abstract

Garlic has been known to be effective against the gastrointestinal diseases which can be induced by production of oxygen-derived free radical. It has been shown that bamboo salt is effective on the treatment and prevention of various gastrointestinal disorders. Bamboo salt is a processed salt invented by a Korean, ll-Hoon Kim. It has been reported that garlic and bamboo-salt are useful to the treatment of gastric disorders in Korea. To clarify the protective mechanism of the garlic-bamboo salt mixture, the gas-tropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. In this study, we found that the garlic-bamboo salt mixture reduced the severity of hemorrhagic lesion in gastric mucosa in the rats. In addition, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) were significnatly increased and the total content of GSH was recovered. From those results, we concluded that the protective effect of the garlic-bamboo salt mixture on gastropathy in rats is its ability to recover the level of GSH and to increase the activities of the free radical scavenging enzymes (SOD, GPx, GR).

Keywords

References

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