Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The effects of Rhizoma Acori Graminei water extract in Alzheimer's Disease Model induced by pCT105

pCT105로 유도된 치매모델에서 석창포(石菖蒲) 수추출액(水抽出液)이 미치는 영향

  • Choi, Hyuk (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Sang-Ho (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Dae-Yong (Department of Oriental Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Ahn, Dae-Joong (Joonghwa Hospital of oriental medicine) ;
  • Kang, Won-Hyung (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lyu, Yeoung-Su (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University)
  • 최혁 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 김상호 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 이대용 (원광대학교 한의과대학 한방내과학교실) ;
  • 안대종 (중화한방병원) ;
  • 강형원 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 류영수 (원광대학교 한의과대학 한방신경정신과학교실)
  • Published : 2002.12.31
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Abstract

Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the future AD will be the largest problem in public health service. From old times, Much medicines have been used for treatment of dementia, but there is no medicine having obvious effect. AD is one of brain retrogression disease. So We studied on herbal medicine that have a relation of brain retrogression. From old times, In Oriental Medicine, Rhizoma Acori Graminei has been used for disease in relation to brain retrogression. We studied on the effects of anti-Alzheimer in pCT105-induced neuroblastoma cell lines by Rhizoma Acori Graminei extract As the result of this study, In RAG group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of Neuroblastoma cells by CT105 expression is promoted. These results indicate that RAG possess strong inhibitory effect of apoptosis in the nervous system and repair effect against the degeneration of Neuroblastoma cells by CT105 expression.

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