Journal of Sasang Constitutional Medicine (사상체질의학회지)

The Society Of Sasang Constitutional Medicine (사상체질의학회)
권호 표지

Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Sasang Constitution in Patients with Cerebral Infarction

뇌경색 환자의 안지오텐신 전환요소 유전자 다형성과 사상체질

  • Bae, Young-Choon (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Kweon, Deog-Yun (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Kim, Kyung-Yo (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Kim, Il-Hwan ;
  • Ju, Jong-Chun (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.)
  • 배영춘 (원광대학교 한의과대학 사상체질의학교실) ;
  • 권덕윤 (원광대학교 한의과대학 사상체질의학교실) ;
  • 김경요 (원광대학교 한의과대학 사상체질의학교실) ;
  • 김일환 (동신대학교 한의과대학 사상체질의학교실) ;
  • 주종천 (원광대학교 한의과대학 사상체질의학교실)
  • Published : 2002.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

The correlation between angiotensin converting enzyme (ACE) polymorphisms and cerebral infarction (CI) has been controversial. Such controversy may be due to different classifications of cerebrovascular diseases and ethnic differences. I studied the correlation between ACE genotypes and CI patients by case-control study in the Korean population. I also classified CI patients and control group into four types according to Sasang constitutional medicine. Furthermore I investigated the correlation among ACE genotypes, CI and Sasang constitutions. The frequencies of D allele were 0.32 in subjects with CI and 0.40 in the control group without CI (X2=0.128, p=0.720). In patients with CI, the frequency of Taeumins, one of four Sasang constitutional types, was significantly higher than that in controls (X2=15.425, p<0.00l). I did not find any correlation between ACE polymorphism and CI in Koreans. However, there were significant differences in allele frequencies between Koreans and Europeans, while similarities were shown to those of Japanese and Chinese populations.

Keywords