Journal of Sasang Constitutional Medicine (사상체질의학회지)

The Society Of Sasang Constitutional Medicine (사상체질의학회)
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Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX

조위승청탕(調胃升淸湯) 전탕액(煎湯液)이 XO/HX에 의해 손상(損傷)된 배양(培養) 해마신경세포(海馬神經細胞)에 미치는 효과(效果)

  • Kim, Hyoung-Soon (Dept. of Sasang Constitutional medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Kim, Kyung-Yo (Dept. of Sasang Constitutional medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Go, Gi-Deok (Dept. of Sasang Constitutional medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Kim, Il-Hwan ;
  • Song, Seung-Yun (Dept. of Sasang Constitutional medicine, College of Oriental Medicine, Wonkwang Univ.)
  • 김형순 (원광대학교 한의과대학 사상체질의학교실) ;
  • 김경요 (원광대학교 한의과대학 사상체질의학교실) ;
  • 고기덕 (원광대학교 한의과대학 사상체질의학교실) ;
  • 김일환 (동신대학교 한의과대학 사상체질의학교실) ;
  • 송승연 (원광대학교 한의과대학 사상체질의학교실)
  • Published : 2002.04.30
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Abstract

Jowiseungcheongtang(JST) has been in Sasang constitution medicine for many years as a therapeutic agent for cerebral disease. But the effect of Jowiseungcheongtang(JST) on neurotoxicity is not known. The purpose of this study was to determine the effects of Jowiseungcheongtang(JST) on the hippocampal cell injured by Xanthine Oxidase/Hypoxanthine. The results were as follows: 1. XO/HX decreased the survival rate of the cultured hippocampal cells on NR assay and MTT assay. 2. JST water extract have efficacy of decreasing a amount of lipid peroxidation increased by XO/HX in cultured hippocampal cells. 3. JST water extract have efficacy of increasing DNA synthesis decreased by XO/HX in cultured hippocampal cells. From the above results, It is concluded that JST has marked efficacy in preventing cultured hippocampal cells from the damages by XO/HX.

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