Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of the Water Extract of Albizzia julibrissin on Cell Cycle Progression in the Human Leukemic Jurkat Cells

백혈병세포주 Jurkat의 세포주기 억제에 미치는 합환피(Albizzia julibrissin) 물 추출물의 효과

  • Hwang, Sang-Gu (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Hyung-Chul (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Dae-Geun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • An, Won-Gun (Department of Biology, College of Natural Sciences, Kyungpook University) ;
  • Jeon, Byung-Hun (Department of Biology, College of Natural Sciences, Kyungpook University)
  • 황상구 (원광대학교 한의과대학 한의학과 병리학교실) ;
  • 이형철 (원광대학교 한의과대학 한의학과 병리학교실) ;
  • 김대근 (원광대학교 한의과대학 한의학과 병리학교실) ;
  • 안원근 (경북대학교 자연과학대학 생물학과) ;
  • 전병훈 (경북대학교 자연과학대학 생물학과)
  • Published : 2002.03.30
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Abstract

Albizzia julibrissin belonging to the family Leguminosae has been used for the treatment of contusion, sore throat, amnesia, and insomnia in Oriental traditional medicine. The water extract of A. julibrissin induced apoptosis in Jurkat T-acute lymphoblastic leukemia (ALL) cells as measured by cell morphology. The capability of this herb medicine to induce apoptosis was associated with proteolytic cleavage of specific target protein such as beta-catenin protein suggesting the possible involvement of caspases. The purpose of the present study is also to investigate the effect of A. julibrissin on cell cycle progression. Our results showed that GI checkpoint related gene products (cyclin D1, cyclin dependent kinase 4, retinoblastoma, E2F1) were decreased in their protein levels in a dose-dependent manners after treatment of the extract. These results indicate that the increase of apoptotic cell death by A. julibrissin may be due to the inhibition of cell cycle progression in wild type p53-lacking Jurkat cells.

Keywords

References

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