Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-diabetic Effects of Mixed Water Extract from Ginseng Radix Rubra, Acanthopanacis Cortex, and Cordyceps

홍삼.가시오가피.동충하초 혼합수엑스의 항당뇨작용

  • Published : 2002.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

The effect of water extract composed of panax ginseng radix rubra, acanthopanacis cortex, and cordyceps (PAC) on diabetic animal models were investigated in two different diabetic animal models. FAC water extract significantly reduced the plasma glucose levels on day 30 as compared with the diabetic control group in $KKA^Y$ obese, hyperglycemic and hyperglycemic and hyperinsulinemic mice, and also reduced the plasma glucose levels as well as total cholesterol in multiple low dose (MLD) strep tozotocin-induced diabetic SD rats. PAC water extract also showed an inhibitory effect on reduction of body weight and on development of MLD STZ-induced diabetic state. Elevated kidney hypertrophy, which is a characteristic feature shown in early stage of diabetic nephropathy and calculated as the ratio of kidney mass (g) relative to the body weight (g), was also markedly improved in PAC water extract- treated group as compared to the diabetic control group. Taken together, these data suggest that PAC water extract may have a potential as a antidiabetic agent in type 2 diabetes mellitus.

Keywords

References

  1. 육창수(1981) 한국약품식물자된도감, 276: 진명출판사, 서울
  2. 육창수(1972) 현대 본초학, 117: 고문사, 서울
  3. 江蘇新醫學院(1982) 中約大辭典, 28: 成輔社, 상해
  4. Sanata, S., Kondo, N., Shoji, J., Tanaka, O. and Shibata. S. (1974) Studies on the saponins of ginseng. I. Structure of ginseng-R_0, Rb_1, Rb_2, Rc and Rd. Chem. Pharm. Bull, 22(2) : 421 https://doi.org/10.1248/cpb.22.421
  5. Kitagawa, I., Taniyama, T., Shibuya, H., Nota, T. and Yoshikawa, M. (1987) Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): Comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root. Yakugaku Zasshi. 107(7): 495-505 https://doi.org/10.1248/yakushi1947.107.7_495
  6. Kimura, M., Waki L., Chujo, T., Kikuchi, T., Hiyama, C., Yamazaki, K. and Tanaka, O. (1981) Effects of hypoglycemic components in Ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from pefused rat pancreas. J. Pharm. Dyn., 4(6): 410-417 https://doi.org/10.1248/bpb1978.4.410
  7. Yokozawa, KobaYashi, T., Oura, H. and Kawashima, Y. (1985) Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb_2 in streptozotocin-diabetic rats. Chem. Pharm. Bull., 33: 869-872 https://doi.org/10.1248/cpb.33.869
  8. 김춘미, 한규선(1985) 인삼 단백질의 방사선 방어작용. 약학회지, 29(5): c
  9. Xu, RS., Feng, SC., Fang, ZY., Ye, CCl., Zhai, SK. and Shen, ML. (1983) Polysaccharide components of the roots of Acanthopanax senticosus. Kexue Tongbao, 28: 185-187
  10. Shao, CJ., Kasai, R., Xu, JD. and Tanaka, O. (1989) Saponins from leaves of Acanthopanax senticosus Harms., Ciwujia : Structure of ciwujianoside C_1, C_2, C_3, C_4, D_1, D_2 and E. Chem. Pharm. Bull., 36: 601-608
  11. Shao, CJ, Kasai, R., Xu, JD. and Tanaka, O. (1989) Saponins from leaves of Acanthopanax senticosus Harms., Ciwujia : Structure of ciwujianoside A_1, A_2, A_3, A_4 and D_3_. Chem. Pharm. Bull., 37: 42-45 https://doi.org/10.1248/cpb.37.42
  12. Hikino, H., Takahashi, M., Otake, K. and Konno, C. (1986) Isolation and hypoglycemic activity of eleuthrans A, B, C, D, E, F and G, glycans of Acanthopanax senticosus roots. J. Nat Prod, 49: 193-297 https://doi.org/10.1021/np50044a001
  13. Xu, RS., Feng, SC., Fan, ZY. and Zhai, SK. (1980) Immunopotentiating polysaccharides of Acanthopanax senticosus, Chem. Prod. Proc. Sino-Am., Symp., 271-274
  14. Medon, PJ., Ferguson, PW., and Watson, CF. (1984) Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo in vitro. J. Ethnopharmacol. 10: 235-241 https://doi.org/10.1016/0378-8741(84)90005-9
  15. Hacker B. and Medon PJ. (1984) Cytotoxic effects of Eleutherococcus senticosus aquous extracts in combination with N^6-$\bigtriangleup$^2-isopentenyl) adenosine and 1--$\beta$-D-arabinofuranosy1 cytosine against L 1210 leukemia cells. J. Pharm. Sci. 73: 270-272 https://doi.org/10.1002/jps.2600730235
  16. Yang JC., Xu Hz. and Lin TS. (1984) Interferon induction by Acanthopanax senticosus polysaccharide and by sodium carboxymethyl starch in S 801 and S 7811 cell culture. Chin. J. Microbiol. Immunol., 4: 329-330
  17. Takasugi, N., Moriguchi, T., and Fuwa, TS. (1985) Effects of Eleutherococcus senticosus and its components on rectal temparature, body and grip tones, motor coordination and exploratory and spotaneous movements in acute stressed mice. Shoyakugaku Zasshi, 39: 232-237
  18. Nishiyama, N. and Kamegaya, T. (1985) Effect of Eleutherococcus senticosus and its components on sex and learning-behaviors and tyrosine hydroxylase activities of adrenal gland and hypothalamic regions in chronic stressed mice. Shoyakugaku Zasshi, 39: 238-242
  19. Fang JN., Proksch A. and Wagner H. (1985) Immunologically active polysaccharides of Acanthopanax senticosus. Phytochemistry, 24: 2619-2622 https://doi.org/10.1016/S0031-9422(00)80681-0
  20. Barenboim GM., Sterline AG., Bebyakova NV, Ribokas AA. and Fuks BB. (1986) Investigation of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. VIII. Investigation of natural killer activation by the Eleutherococcus extract. Khim. Farm. Zh., 20: 914-917
  21. Bohn, B., Nebe, CT. and Birr, C. (1987) Durch fluzy tometrische Untersushungen auf Immunomodulatorische Wirkungen von Eleutherococcus senticosus extiact. Arzneim anticancer effect in leaves. Yakhak Hoeji, 37: 1193-1196
  22. Ahn YJ., Park SJ., Lee SG., Shin SC. and Choi DH. (2000) Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp. J Agric Food Chem, 48(7): 2744-2748 https://doi.org/10.1021/jf990862n
  23. Zhao-Long W., Xiao-Xia W. and Wei-Ying C. (2000) Inhibitory effect of Cordyceps sinensis and Cordyceps mititaris on human glomerular mesangial cell proliferation induced by native LDL. Cell Biochem Funct, 18(2): 93-97 https://doi.org/10.1002/(SICI)1099-0844(200006)18:2<93::AID-CBF854>3.0.CO;2-#
  24. Ikumoto T., Sasaki S., Namba H., Toyama R., Moiitoki H. and Mouri T. (1991) Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria. Yakugaku Zasshi, 111(9): 504-509
  25. Toshinan Takamura., Hitoshi Ando. and Yukihiro Nagai. (1999) Pioglitazone prevents mice from multiple low-dose streptozotocin-induced insulitis and diabetes. Diabetes Res. Clin. Pract, 99: 107-114
  26. Rakesh Kakkar., Subrahmanyam V. and Mantha. (1997) Andoxydant defense system diabetic kidney : A time course study. Life Sciences, 60: 667-679 https://doi.org/10.1016/S0024-3205(96)00702-3