Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Antidiabetic Activity of Opuntia ficus-indica var. sabotan on db/db Mice

db/db 당뇨모델 생쥐에서 손바닥 선인장의 항당뇨 효과

  • Published : 2002.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Opuntia ficus-indica var. sabotan was administered with diet for 5 weeks on db/db diabetic mice and its antidiabetic activity was investigated. Leaves of Opuntia ficus-indica var. sabotan inhibited the increase of body weight, glucose elevation in blood and urine, and protein excretion in urine, and protein excretion in urine. Opuntia ficus-indica var. sabotan also inhibited the intestinal maltase and sucrase activity on db/db Mice loaded with maltose and sucrose. However, it did not significantly lower HbAlc in blood of db/db mice. These results suggest that leaves of Opuntia ficus-indica var. sabotan could be effective on insulin-independent diabetic mellitus type 2.

Keywords

References

  1. http://www.richis.org/dbbank/pratic/stat2/99dttab1.htm (2002)
  2. http://www.nso.go.kr/cgi-bin/sws_999.cgi (2002)
  3. Lee, Y. C., Hwang, K, H., Han, D. H. and Kim, S. D. (1997) Compositions of Opuntia ficus indica. Korean J. Food Sci. Technol. 29(5): 847-853
  4. http://www.bukjeju.agri.cheju.kr/total/good/001.htm (2002)
  5. http://members.tripod.co.kr/orange72/sub-2 (2002)
  6. Bradford, M. (1976) A rapid and sensidve method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem., 72: 248-254 https://doi.org/10.1016/0003-2697(76)90527-3
  7. Ladas, S. D., Frydas, A., Papadopoulos, A. and Raptis, S. A. (1992) Effect of -glucosidase inhibitors on mouth to caecum transit time in humans. Gut. 33: 1246-1248 https://doi.org/10.1136/gut.33.9.1246
  8. Couet, C., Ulmer, M., Bau, H. M. and Debry, G. (1989) Metabolic effects of acarbose in young heathy men. European. J. Climical Nutrition., 43: 187-196
  9. Stanley, M. L. and Sergio, B. Chronic effects of an glucosidase inhibitor (Bay O 1248) on intestinal disaccharidase activity in normal and diabedc mice. J. Pham. & Experomental Therapeutics. 240: 132-137 (1986)
  10. Choue, R. W., Chung, S. H. and Kim, M. S. Effect of Mori Folium column Fraction on Intestinal alpha-glycosidase Activity in Mice Administered with a high carbohydrate-containing diet. J. Pharmaceutical Society cf Korea. 41(4): 484-491 (1997)
  11. Allen, D. W., Schrodeder, W. A. and Balog, J. (1958) Observation on the chromatographic heterogeneity of normal adult & fetal human hemoglobin. J. Am. Chem. Soc., 80: 1628 https://doi.org/10.1021/ja01540a030
  12. Miller, J. A., Gravallesse, E. and Bunn, H. F. (1980) Nonenzymetic glycosylation of erythrocyte membrane protein. Clin. Invest. 65: 896 https://doi.org/10.1172/JCI109743
  13. Yue, D. K., Morris, K., Molennun, S. and Turde, J. R. (1980) Glycosylation of plasma protein and it's relation to glycosylated Hb in diabetes. Diabetes. 29: 296- https://doi.org/10.2337/diab.29.4.296