Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Preparation and Characterization of Solid Dispersion of Ipriflavone with Polyvinylpyrrolidone

  • Jeong, Je-Kyo (Department of Polymer Science and Technology, Chonbuk National University) ;
  • Kim, Jung-Hoon (Department of New Organic Materials Engineering, Chonbuk National University) ;
  • Khang, Gil-Son (Department of Polymer Science and Technology, Chonbuk National University) ;
  • Rhee, John M. (Department of Polymer Science and Technology, Chonbuk National University) ;
  • Lee, Hai-Bang (Biomaterials Laboratory, Korea Research Institutes of Chemical Technology)
  • Published : 2002.09.20
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Abstract

Solid dispersions of ipriflavone with PVP were prepared by a spray-drying method in order to improve the bioavailability. They were measured with scanning electron microscopy, differential scanning calorimetry, x-ray powder diffraction, and Fourier transform infrared spectroscopy to evaluate the physicochemical interaction between ipriflavone and PVP and study the correlation between these physicochemical characteristics and bioavailability. Ipriflavone exhibited crystallinity, whereas PVP was almost amorphous. The area of the endotherm $({\Delta}H)$ of freezer milled ipriflavone, freezer milled ipriflavone physically mixed with freezer milled PVP, and physically mixed ipriflavone with PVP was almost the same, whereas ${\Delta}H$ of the solid dispersed ipriflavone with PVP was much smaller than that of the other preparation types. Also, the crystallinity and the crystal size of ipriflavone in the solid dispersed ipriflavone with PVP were much smaller than those of the other preparation types. From the in vivo test, the AUC of the solid dispersed ipriflavone with PVP was approximately 10 times higher than that of the physically mixed ipriflavone with PVP. The solid dispersion using the spray-drying method with a water-soluble polymer, PVP, may be effective for the improvement of the bioavailability.

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