Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Central nervous system depressant effect of hot water extract of Ocimum sanctum Linn. (Labiateae)

  • Published : 2002.08.30
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Abstract

A battery of neuropharmacological experiments showed the hot water extract of Ocimum sanctum Linn. (Labiateae) had a depressant effect on the central nervous system (CNS), but the aqueous extract showed no effect on it. The hot water extract reduced the spontaneous locomotor activity, exploratory head dipping, propulsive locomotion and exploratory ambulation as well as prolonged the pentobarbital induced sleeping time. The depressant effect starts from 60 minutes after the drug administration and continued to 180 minutes. The drug may exert central depressant effect by interfering with the function of the cortex.

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References

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