Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effect of Banhasasim-tang on the Cardiac Toxicity and clinical symptom induced by Doxorubicin

반하사심탕(半夏瀉心湯)이 Doxorubicin에 의해 유발(誘發)된 심장독성(心臟毒性) 및 임상증상(臨床症狀)에 미치는 영향(影響)

  • Shin Min-Kyu (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Hwang Hui-Jeung (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Kim Sang-Chan (Department of Formulae Pharmacology, College of Oriental Medicine, Kyungsan University) ;
  • Byun Joon-Seok (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University)
  • 신민규 (경산대학교 한의과대학 내과학 교실) ;
  • 황희정 (경산대학교 한의과대학 내과학 교실) ;
  • 김상찬 (경산대학교 한의과대학 방제학 교실) ;
  • 변준석 (경산대학교 한의과대학 내과학 교실)
  • Published : 2002.06.20
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Abstract

The effect of Banhasasim-tang extracts on the cardiac toxicity and general symptom induced by Doxorubicin administration(Three injection protocol) were monitored using male ICR mice. The changes of body weight, clinical signs, necropsy findings and organ weights of heart were observed. The results were as followed. 1. Decrease of body weight after Doxorubicin treatment were dose-dependently inhibited by Banhasasim-tang extracts. 2. The degrees of anorexia, ataxia and dehydration that were observed in Doxorubicin treatment group were dose-dependently inhibited by Banhasasim-tang extracts. 3. Increase of absolute and relative heart weight observed in Doxorubicin treatment group were dose-dependently inhibited by Banhasasim-tang extracts. In addition. the degrees of heart congestion and enlargement were significantly and dose-dependently decreased after Banhasasim-tang extracts dosing groups compared to that of Doxorubicin treatment group. In conclusion, the toxicity of Doxorubicin treatment(decrease of body weights, clinical signs such as anorexia, ataxia and dehydration, changes of organ weights of heart) was inhibited and/or prevented by Banhasasim-tang extracts. According to these results. it is considered that Banhasasim-tang has some preventive effect against to toxicity induced by Doxorubicin.

Keywords

References

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