Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Anti-leukemic effects of JIPAESAN and its components on leukemic cells HL-60

인간백혈병(人間白血病) 세포주(細胞株)에서 지패산(芷貝散)의 작용(作用)에 관(關)한 연구(硏究)

  • Hwang Kee-Myoung (Department of Oriental Medical Prescription Wonkwang University)
  • 황기명 (원광대학교 한의과대학 방제학교실)
  • Published : 2002.06.20
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Abstract

In the hope of identifying anti-leukemic agents from traditional herbal medicines. this study was designed to investigate the anti-leukemic effects of the herbal medicine Jipaesan, which is composed of Angelica Dahurica and Fritillariae Verticillata. in acute promyeloid leukemia HL-60 cells. Jipaesan showed anti-proliferative effect through the induction of differentiation and apoptosis in HL -60 cells. Verticinone as a major differentiating agent and imperatorin as major apoptosis-inducing agent were isolated from the water extracts of F. Verticillata and A. Dahurica, respectively. Combined treatment of HL-60 cells with two major compounds showed synergy in the induction of differentiation. Since the induction of differentiation and/or apoptosis has therapeutic values in curing acute leukemic diseases. Jipaesan could be useful as an anti-leukemic agent.

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References

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