The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Mechanism Study of Bangpungtongseongsan(BTS) on the Cerebral Hemodynamics in Mice

방풍통성산(防風通聖散)이 백서(白鼠)의 뇌혈류량역학(腦血流力學)에 미치는 기전(機轉) 연구(硏究)

  • Jeon, Hong-Youl (Dept. of 2nd internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Jeon, Sang-Yun (Dept. of 2nd internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Hong, Suk (Dept. of 2nd internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Kang, Hwa-Jeong (Dept. of 2nd internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Kim, Jong-Suk (Dept. of radiology, Dongshin University Oriental Medicine Hospital) ;
  • Kim, Kyung-Sun (Dept. of 2nd internal Medicine, College of Oriental Medicine, Dongshin University)
  • 전홍열 (동신대학교 한의과대학 심계내과학 교실) ;
  • 전상윤 (동신대학교 한의과대학 심계내과학교실) ;
  • 홍석 (동신대학교 한의과대학 심계내과학교실) ;
  • 강화정 (동신대학교 한의과대학 심계내과학교실) ;
  • 김종석 (동신대학교 부속 한방병원 방사선과) ;
  • 김경선 (동신대학교 한의과대학 심계내과학교실)
  • Published : 2002.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : Bangpungtongseongsan(BTS) has been used in oriental medicine for many centuries as a prescription for a heat syndrome of apoplexy. The effects of BTS on the vascular system are not well known. This study is designed to identify the effects of BTS on the regional cerebral blood flow(rCBF), arterial blood pressure and action mechanism in mice. Methods : We measured the change of rCBF and BP by BTS. Secondly, we investigated changes of rCBF and BP for 30 minutes interval after venous inject 0.01, 0.1, 1.0, 10.0mg/kg each density BTS infusion into mice, which were premanaged with methylene blue(10mg/kg, i.v), indomethacin(3mg/kg, i.v.), propranolo(3mg/kg, i.v.) for 30minutes. Results : rCBF increased significantly by BTS in a dose-dependent and BP was not affected by BTS in mice. Pretreatment with methylene blue significantly inhibited rCBF increased by BTS and aceelrated BP not affected by BTS. Pretreatment with indomethacin significantly inhibited rCBF increased by BTS and inhibited BP not affected by BTS. Conclusion : These results show that BTS causes the increasement of rCBF and non-change of BP. The action mechanism is related to prostaglandid activated by cyclooxygenase.

Keywords

References

  1. 신경외과학 대한신경외과학회
  2. 대한신경외과학회지 v.18 no.3 Doppler Ultrasound를 이용한 뇌기저 동맥의 혈류속도 측정 권병덕
  3. 실용중의심혈관병학 屈松栢
  4. 精校黃帝內經 洪元植
  5. 金궤要略 張仲景
  6. 巢氏諸病源候論 v.二 巢元方
  7. 素問玄機原病式 劉完素
  8. 河間三六書 劉完素
  9. 東垣十種醫書 李고
  10. 丹溪心法附錄(上) 方廣
  11. 文淵閣書庫全書, 中醫學大系 v.十二 宣明方論 劉宗素
  12. 千今備急要方 v.八 孫思邈
  13. 方藥合編 黃度淵
  14. 韓方外科 蔡炳允
  15. 경희약대논문집 v.5 방풍통성산이 가토혈청지질함량에 미치는 영향 金壽億
  16. 방풍통성산의 진통 소염 해열 및 항균작용에 관한 실험적 연구 成賢濟
  17. 방풍통성산이 고혈압, 고지혈증에 미치는 영향 李南勳
  18. 방풍통성산이 CCL, 중독백서의 혈액상에 미치는 영향 孟貞均
  19. 방풍통성산 전탕액이 진통,항경련, 진정 및 장관운동에 미치는 영향 李永宇
  20. 방풍통성산이 백서의 비만증 및 비만세포에 미치는 영향 申秉澈
  21. 사상의학회지 v.10 no.2 방풍통성산 전탕액의 면역조절작용 李昌奎
  22. 방풍통성산이 비만유도백서의 체증 및 지질대사에 미치는 영향 安貞美
  23. 혜화의학 v.4 no.1 중풍초기환자에 대한 방풍통성산의 임상적 연구 姜和廷
  24. 내과학 서울대학교의과대학내과학교실(編)
  25. Stroke v.21 Pathophysiology of Ischemic Stroke as Determined by PET Heiss, W.D.
  26. <儒門事親>校注 張子和
  27. 醫學心悟 程國彭
  28. 普濟方 朱소
  29. 醫學入門 李정
  30. 萬病回春 공廷賢
  31. 東醫寶鑑 許浚
  32. 南士堂醫書全集 陳念祖
  33. 醫方集解 汪인庵
  34. 方劑學 李尙仁
  35. 바른 方劑學 康舜洙
  36. 동의신계내과학 朴憲在(外)
  37. 한방안이비인후과 蔡炳允
  38. 漢方醫學講座 矢數道明
  39. 이우주의 약리학 강의 김경환
  40. Statisastical Methods Snedecor, G.H.;Cocharn, W.G.
  41. 생리학 성호경(外)
  42. 본초학 전국한의과대학 본초학교실(編)
  43. Principles of laser-Doppler flowmetry Bonner, R.F.(외);Shepherd, A.P.(ed.);Berg, P.A.(ed.)
  44. British Journal of Pharmacology v.114 Increase of meningeal blood flow electrical stimulation of rat duramater encephali Meiko(외)
  45. Brain Research v.669 Trigeminal ganglion stimulation increases facial skin blood flow in the rat. a major role for calcitonin gean-related peptide Jane, E.K.(외)
  46. Stroke v.29 no.6 Role of inducible nitric oxide synthase and cycloxygenase-2 in endotoxin-induced cerebral hyperemia Okamoto, H.(외)
  47. 동의병리학회지 v.13 no.2 수종 한약재가 혈압 및 국소뇌혈류량에 미치는 영향 申榮日(外)
  48. FASEB Journal v.7 Nitric oxide sythesis inhibition induced leukocyte adhesion via superoxide and master cell Kubes, P.(외)
  49. Nature v.327 Nitric oxide release accounts for the biology activity of endothelium derived relaxing factor Palmer, P.M.J.;Ferrige, A.G.;Monacada, S.
  50. Critical Care Medicine v.20 Nitric oxide systhesis serves to reduce hepatic damage during acute murine endotoxemia Harbrecht, B.G.;Billiar, T.R.;Stadler, T.;Demetris, A.J.;Ochoa, J.B.;Curran, R.D.;Simmons, R.L.
  51. Stroke v.17 Rat middle cerebral artery occlusion. Evaluation of the model and development of a neurologic examination Bederson, J.B.(et al.)