Application of Intensity Modulated Radiation Therapy (IMRT) in Prostate Cancer

전립선암에서 강도변조방사선치료 (Intensity Modulated Radiation Therapy)의 적용

  • Park Suk Won (Department of Radiation Oncology, College of Medicine, Hallym University) ;
  • Oh Do Hoon (Department of Radiation Oncology, College of Medicine, Hallym University) ;
  • Bae Hoon Sik (Department of Radiation Oncology, College of Medicine, Hallym University) ;
  • Cho Byung Chul (Department of Radiation Oncology, College of Medicine, Hallym University) ;
  • Park Jae Hong (Department of Radiation Oncology, College of Medicine, Hallym University) ;
  • Han Seung Hee (Department of Radiation Oncology, College of Medicine, Hallym University)
  • 박석원 (한림대학교 의과대학 방사선종양학교실) ;
  • 오도훈 (한림대학교 의과대학 방사선종양학교실) ;
  • 배훈식 (한림대학교 의과대학 방사선종양학교실) ;
  • 조병철 (한림대학교 의과대학 방사선종양학교실) ;
  • 박재홍 (한림대학교 의과대학 방사선종양학교실) ;
  • 한승희 (한림대학교 의과대학 방사선종양학교실)
  • Published : 2002.03.01

Abstract

This study was done to implement intensity-modulated radiation therapy (IMRT) for the treatment of primary prostate cancer and to compare this technique with conventional treatment methods. A 72-year-old male patient with prostate cancer stage T2a was treated with IMRT delivered with dynamic multi-leaf collimation. Treatment was designed using an inverse planning algorithm, which accepts dose and dose-volume constraints for targets and normal structures. The IMRT plan was compared with a three-dimensional (3D) plan using the same 6 fields technique. Lower normal tissue doses and improved target coverage were achieved using IMRT at current dose levels, and facilitate dose escalation to further enhance locoregional control and organ movement during radiotherapy is an important issue of IMRT in prostate cancer.

최근 들어 새로운 방사선치료법인 강도변조방사선치료가 많은 종류의 종양치료에 적용되어 치료에 따른 부작용을 줄이고 치료율을 향상시키려는 노력들이 이루어지고 있다. 특히 전립선암에서 강도변조방사선치료법을 적용하여 삼차원입체조형치료에 비해 향상된 선량분포와 이로 인한 주위 정상조직의 방사선량을 줄임으로써 더욱 많은 양의 방사선을 전립선에 투여할 수 있고 이로 인하여 치료율의 상승을 기대할 수 있게 되었다. 저자들은 강도변조방사선치료를 전립선암에 적용하였기에 이에 대한 문헌고찰과 함께 치료과정을 보고하고자 한다.

Keywords

References

  1. Hanks GE, Martz KL, Diamond JJ. The effect of dose on local control of prostate cancer. Int J Radlat Oncol Biol Phys. 1988;15:1299-1306 https://doi.org/10.1016/0360-3016(88)90224-6
  2. Zelefsky MJ, Leibel SA, Gaudin PB, et al. Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer. Int J Radiat Oncol Biol Phys 1998;41:491-500 https://doi.org/10.1016/S0360-3016(98)00091-1
  3. Sandler HM, McShan DL, Lichter AS. Potential improvement in the results of Irradiation for prostate carcinoma usingimproved dose distribution. Int J Radiat Oncol Biol Phys 1991;22:361-367
  4. Dearnaley DP, Khoo VS, Norma AR, et al. Comparison of radiation side-effects of conformal and conventional radiotherapy In prostate cancer: A randornised trial. Lancet 1999;353:267-272 https://doi.org/10.1016/S0140-6736(98)05180-0
  5. Burman C, Chui C, Kutcher G, et al. Planning, delivery, and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator: A strategy for large-scaleimplementation for the treatment of carcinoma of the prostate. Int J Radiat Oncol Biol Phys 1997;39:863-873 https://doi.org/10.1016/S0360-3016(97)00458-6
  6. Gert OM, Luc Vt, Werner G, et al. Radiotherapy of prostate cancer With or Without intensity modulated beams: a planning comparison. Int J Radiat Oncol Biol Phys 2000;47:639-648 https://doi.org/10.1016/S0360-3016(00)00419-3
  7. Michael JZ, Zvi F, Laura H, et al. Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancer. Radiother Oncol 2000;55:241-249 https://doi.org/10.1016/S0167-8140(99)00100-0
  8. Christopher MN, David JC, Vivian PC, et al. Reduction of small and large bowel irradiation using an optimized intensity-modulated pelvic radiotherapy technique in patients with prostate cancer. Int J Radlat Oncol Biol Phys 2000;48:649-656 https://doi.org/10.1016/S0360-3016(00)00653-2
  9. Lee WR, Hanks GE, Hanlon A, et al. Hunt, Lateral rectalshielding reduces late rectal morbidity following high dosethree-dimensional conformal radiation therapy for clinically localized prostate cancer: Further evidence for a significant dose effect. Int J Radiat Oncol Biol Phys 1996;35:251-257 https://doi.org/10.1016/0360-3016(96)00064-8
  10. Nutting C, Dearnaley DP, Webb S. Intensity modulatedradiation therapy: A clinical review. British J Radlol 2000;869:459-469
  11. Dasarahally SM, Patrick AK, Twyla RW. Short-course Intensity-modulated radiotherapy for localized prostate cancer with dally transabdominal ultrasound localization of the pros-tate gland. Int J Radiat Oncol Biol Phys 2000;46:575-580 https://doi.org/10.1016/S0360-3016(99)00454-X
  12. David EW, Thomas DP, Jen-San T, et al. The New England medical center prostate cancer IMRT experience. International symposium, 3 D conformal radiation therapy and Intensity modulation radiation therapy in the new millennium. 1999
  13. Pollack A, Zagars GK, Starkschall G, et al. Conventionalvs. conformal radiotherapy for prostate cancer: Preliminaryresults of dosimetry and acute toxicity. Int J Radlat Oncol Biol Phys 1996;34:555-564 https://doi.org/10.1016/0360-3016(95)02103-5
  14. Bin ST, Wei-Yuan M, Barry MU, et al. Intensity-modulated radiation therapy (IMRT) for prostate cancer with the use of a rectal balloon for prostate immobilization: acute toxicity and dose volume analysis, Int J Radiat Oncol Biol Phys 2001;4:705-712
  15. Morr T, DiPetrillo T, Tsai J, D. et al. Clinical use of daily transabdominal ultrasound localization with Intensity modulated radiation therapy (IMRT) for prostate cancer. Int J Radiat Oncol Biol Phys 2000;48:308