Yonsei Medical Journal

Yonsei Univ College Medicine (연세대학교의과대학)
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Familial Correlation and Heritability for Cardiovascular Risk Factors

Jee, Sun-Ha;Suh, Il;Won, So-Young;Kim, Mi-yang

  • Published : 20020400

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Abstract

The goal of this study was to describe the overall genetic contribution of phenotypic variation to cardiovascular disease. The study population included 7,589 family members of 1,891 families, derived from Korean Medical Insurance Corporation. The risk factors considered were systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and high serum cholesterol. The levels of cardiovascular disease risk factors were adjusted for age, gender, smoking and alcohol drinking. Heritability was estimated from the slope of the line linear regression of offspring on mid-parent. All risk factors showed positive familial correlations, and correlations were generally lower for spouses than for parent- offspring pairs. Spouse correlations showed increasing patterns with age. Parents-offspring correlations showed little variation with age, suggesting that the observed correlations with CVD risk factors were primarily due to genetic influences rather than environmental effects. Estimated heritabilities were 26% for BMI, 26% for high serum cholesterol, 19% for SBP, and 9% for DBP. These results highlight the importance of considering genetic factors in studies of cardiovascular risk factors.

Keywords

References

  1. Annual Report on the Cause of Death Statistics National Statistical Office
  2. Am J Epidemiol v.110 Familial aggregation of blood pressure and weight in adoptive families. II. Estimation of the relative contributions of genetic and common enviromental factors to blood pressure correlations between family members Annest, J.L.;Sing, C.F.;Biron, P.;Mongeau, J.
  3. Int J Obes v.12 Familial aggregation of body mass index in ethnically diverse families in Jerusalem. The Jerusalem lipid research clinic Friedlander, Y.;Kark, J.D.;Kaufmann, N.A.;Berry, E.M.;Stein, Y.
  4. Am J Epidemiol v.110 The association of total cholesterol, triglycerides and plasma lipoprotein cholesterol levels in first degree relatives and spouse pairs Garison, R.J.;Casteli, W.P.;Feinleib, M.;Kannel, W.B.;Havlik, R.J.;Padgett, S.J.(et al.)
  5. Am J Epidemiol v.110 Blood pressure aggregation in families Havlik, R.J.;Garrison, R.J.;Feinleib, M.;Kannel, W.B.;Castelli, W.P.;McNaMara, P.M.
  6. Ann Epidemiol v.8 Prevalence of Cardiovascular Risk Factors in South Korean Adults: Results from the Korea Medical Insurance Corporation (KMIC) Study Jee, S.H.;Appel, L.J.;Suh, I.;Whelton, P.K.;Kim, I.S.
  7. Statistical analysis for genetic epidemiology, release 3.1. Computer program package available from department of epidemiology and biostatistics, Rammelkamp center for education and research, Metrohealth campus S.A.G.E.
  8. Introduction to quantitative genetics Falconer, D.S.;Mackay, T.F.C.
  9. Biometrics v.39 Heritability: one word, three concepts Jacquard, A.
  10. Genet Epidemiol v.9 Genetic and environmental effects on blood pressure in a Norwegian sample Tambs, K.;Moum, T.;Holmen, J.;Eaves, L.J.;Neale, M.C.;Lund-Larsen, G.(et al.)
  11. Am J Epidemiol v.116 Association arrays for the study of familial height, weight, lipid, and lipoprotein similarity in three west coast populations Karlin, S.;Williams, P.T.;Farquhar, J.W.;Barrett-Connor, E.;Hoover, J.;Wahl, P.W.(et al.)
  12. Am J Epidemiol v.120 Environmental and genetic sources of familial aggregation of blood pressure in Tecumseh, Michigan Longini, I.M.;Higgins, H.W.;Hinton, P.C.;Moll, P.P.;Keller, J.B.
  13. N Engl J Med v.328 Genetic and environmental influences on serum lipid levels in twins Heller, D.A.;de Faire, U.;Pedersen, N.L.;Dahlen, G.;McClearn, G.E.
  14. Genet Epidemiol v.2 The collaborative lipid research clinics family study: biological and cultural determinants of familial resemblance for plasma lipids and lipoproteins Namboodiri, K.K.;Kaplan, E.B.;Heuch, I.;Elston, R.C.
  15. Stat Methods Med Res v.2 Variance components for statistical genetics: applications in medical research to characteristics related to human diseases and health Hopper, J.L.
  16. Genet Epidemiol v.9 Pedigree analysis of blood pressure in subjects from rural Greece and relatives who migrated to Melbourne, Australia Hopper, J.L.;Macaskill, G.T.;Powles, J.W.;Ktenas, D.
  17. Lancet v.358 Serum cholesterol and haemorrhagic stroke Suh, I.;Jee, S.H.;Nam, C.M.;Kim, H.C.;Appel, L.J.