The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
권호 표지

Effects of Carthami Semen on the Hormones and Cytokines Associated with Bone Metabolism in Ovariectomized Rats

홍화씨가 난소적출 흰쥐의 골대사에 관련된 Hormone과 Cytokine에 미치는 영향

Joo, Byoung-Ju;Kim, Hyoung-Jun;Lee, Dong-Nyoung;Seo, Il-Bok
주병주;김형준;이동녕;서일복

  • Published : 20020000

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Abstract

This study was aimed at proving the effects of Carthami Semen on the hormones and cytokines associated with bone metabolism in ovariectomized rats. Twenty-four female Sprague-Dawley rats were divided into sham operated (normal) group, ovariectomized(control) group, ovariectomized and treated with extract of Carthami Semen(treated) group. Each group was monitored the changes of body weight at 0,3,5,7weeks after treatment, and changes of femur weight, femur/body weight, thickness of compact bone, area of cancellous bone, serum estrogen, serum calcitonin, serum parathonnone, serum tumor necrosis factor-${\alpha}$(TNF-${\alpha}$). serum interleukin-1${\beta}$(IL-1${\beta}$) at 7weeks after treatment. The results can be summerized as follows ; 1. The treated group showed no change in body weight compared with the control group. 2. The treated group revealed significant increases in femur weight and femur/body weight compared with the control group. 3. The treated group showed much thicker compact bone of body of femur than the control group. 4. The area of cancellous bone of distal epiphysis of femur in treated group was increased significantly compared with the control group. 5. The level of serum estrogen showed no change in the treated group compared with the control group. 6. The level of serum calcitonin showed no change in the treated group compared with the control group. 7. The level of serum parathormone was decreased in treated group significantly compared with the control group. 8. The level of serum TNF-${\alpha}$ was decreased in the treated group significantly compared with control group. 9. The level of serum IL -1${\beta}$ showed no change in the treated group compared with the control group. These results indicate that Carthami Semen inhibits bone resorption in ovariectomized rats by it's lowering effects on serum parathormone and TNF-${\alpha}$.

Keywords

References

  1. 中國中醫基礎醫學雜誌 v.7 no.3 補腎方藥對去卵巢所致大鼠骨質疏송症的骨組織ER表達的影響 支會英;李恩
  2. 湖南中醫雜誌 v.17 no.3 骨위湯加減治療原發性骨質疏송症223例 柳金才;劉慶思
  3. 湖北中醫雜誌 v.23 no.2 鍼刺背部兪穴對骨質疏송症腰椎骨密度的影響 王東岩;蔡紅;卓鐵軍
  4. 부인과학 대한산부인과학회
  5. 대한정형외과학회지 v.29 no.5 흰쥐에서 난소 적출술로 유발한 골다공증에 대한 Estradiol의 효과 이명철(등)
  6. 대한정형외과학회지 v.27 백서의 난소제거술후 발생한 골조송증에 대한 Calcitonin의 효과 이환모;한수봉;박병문
  7. 대한정형외과학회지 v.35 no.6 난소 절제 백서에서 Pamldronate의 골다공증 예방효과에 대한 생체역학적 분석 조기현(등)
  8. 대한정형외과학회지 v.32 no.4 골다공증 환자에서의 칼슘 및 활성형 비타민 D 치료후 골밀도의 변화 장준섭;박진오
  9. 대한정형외과학회지 v.33 no.7 난소절제술을 실시한 흰쥐에서 성장호르몬의 골다공증 예방효과 이영구(등)
  10. J Bone Miner Res. v.11 no.2 Ipriflavone inhibits bone resorption in rats:Effect of experimental conditions Cecchini, M.G.;Fleisch, H.;Muhlbauer, R.C.
  11. Obstet Gynecol Surv. v.55 no.1 Prevention of Post menopausal Bone Loss at Lumbar Spine and Upper Femur With Tibolone: A Two-Year Randomised Controlled Trial Beardsworth, S.A.;Kearney, C.E.;Purdie, D.W.
  12. Obstet Gynecol Surv. v.54 no.8 Postmenopausal osteoporosis Watts, N.B.
  13. N Engl J Med. v.344 no.19 Effect of parathyroid hormone (1~34) on fractures and bone mineral density in postmenopausal women with osteoporosis Neer, R.M.(et al.)
  14. Spine v.22 no.24S Consensus summary on the diagnosis and treatment of osteoporosis Andersson, G.B.(et al.)
  15. 今釋 黃帝內經 素問 裵炳哲
  16. 今釋 黃帝內經 靈樞 裵炳哲
  17. 大韓本草學會誌 v.13 no.1 鹿茸이 난소적출로 유발한 흰쥐의 骨多孔症에 미치는 영향 안덕균;심상도
  18. 대한한방내과학회지 v.22 no.2 난소 절제 흰쥐의 골대사에 미치는 骨碎補의 영향 김광진;정지천
  19. 大韓韓方婦人科學會誌 v.12 no.1 大補元煎이 난소 적출로 骨多孔症이 유발된 白鼠에 미치는 영향 조한백;박병렬
  20. 원광대학교 대학원 석사학위 논문 홍화씨 성분 분리 추출물이 치주인대세포와 조골모유사세포의 광물화에 미치는 영향 이광수
  21. 大韓本草學會誌 v.13 no.2 紅花子가 난소절제로 유발된 폐경후 골다공증 흰쥐의 골밀도에 미치는 영향 金美麗;梁在夏;徐富日
  22. 大韓韓方婦人科學會誌 v.14 no.1 紅花子가 卵巢를 摘出한 白鼠의 骨多孔症에 미치는 影響 朴徹勳(등)
  23. J Bone Miner Res. v.13 no.5 A Unitary Model for Involutional Osteoporosis: Estrogen Deficiency Causes Both Type I and Type II Osteoporosis in Postmenopausal Women and Contributes to Bone Loss in Aging Men Riggs, B.L.;Khosla, S.;Melton, L.J.
  24. 병리학 대한병리학회
  25. 韓醫方婦人科學(上) 韓醫方婦人科學 敎授編纂委員會
  26. 大韓鍼灸學會誌 v.15 no.2 骨多孔症의 鍼灸治療에 관한 文獻的 考察 姜成吉;朴英培;安鉉碩
  27. 山東中醫學院學報 v.16 no.2 腎虛證與骨鑛物含量的關係 蔡新吉
  28. 慶山大學校 大學院 博士學位 論文 卵巢摘出된 흰쥐의 骨多孔症에 미치는 影響 田宰官
  29. 完譯 中藥大辭典 金昌玟
  30. 비만학 이론과 실제 대한일차의료학회 비만연구회(編)
  31. 대한의학협회지 v.31 한국인 성인 남녀의 골밀도 용석중(등)
  32. 임상내분비학 민헌기
  33. 임상 부인과 내분비학 구병삼
  34. J Am Geriatr Soc. v.40 no.11 The effect of aging on intact PTH and bone density in women Flicker, L.(et al.)
  35. J Bone Miner Res. v.14 no.7 Estrogen Regulation of Intestinal Calcium Absorption in the Intact and Ovariectomized Adult Rat Bolscher,M.T.(et al.)
  36. J Bone Miner Res. v.14 no.4 Ovariectomized Murine Model of Postmenopausal Calcium Malabsorption Kaul, D.N.;Chen, C.
  37. 대한의학협회지 v.38 no.1 여성호르몬과 골밀도 민용기
  38. J Bone Miner Res. v.11 no.8 Estrogen, cytokines, and Pathogenesis of Postmenopausal Osteoporosis Pacifici, R.
  39. 생리학 이상돈;성호경
  40. Am J Med. v.109 no.4 A Randomized Trial of Nasal Spray Salmon Calcitonin in Postmenopausal Women with Established Osteoporosis: the Prevent Recurrence of Osteoporotic Fractures Study Chesnut, C.H.(et al.)
  41. 대한내분비학회지 v.6 no.2 칼시토닌의 내분비학 김선우
  42. 대한의학협회지 v.38 no.1 부갑상선호르몬과 골밀도 임승길
  43. Clin Endocrinol(Oxf) v.36 no.4 Age-related in bone density, serum parathyroid hormone, calcuium absorption and other indices of bone metabolism in Chinese women Chan, E.L.(et al.)
  44. Endocr Rev. v.21 no.2 Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis Manolagas, S.C.
  45. 대한내분비학회지 v.12 no.2 백서에서 난소절제술 시행후 골밀도와 골수 시토킨의 변화에 대한 연구 박근용