Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
권호 표지

Development of Upgraded Cortical Impact Model(Part II：Functional outcome)

개량형 피질 충격 모델의 개발(제 2 부：기능적 결과)

Choi, Seok-Min;Suk, Jong-Sik;Min, Byung-Kook;Hwang, Sung-Nam;Kim, Young-Baeg;Kim, Jae-Hyun
최석민;석종식;민병국;황성남;김영백;김재현

  • Published : 20021100
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Abstract

Objective：With the technical support from department of mechanical engineering, Korea Advanced Institute of Science and Technology(KAIST), we began to develop a better head trauma model named 'Chung-Ang University Hospital Model 1.0(CAUH-1)' in March 2001 and completed it August 2001. In addition, we conduct functional tests(postural reflex, balance beam test, rotarod test, and etc) to verify this model. Methods：Twelve four hours after moderate head injury(air tank pressure：125psi, impact velocity: 1.34m/sec, depth of deformation：2.5mm, dwell time：84.5msec), we conducted various functional tests. Then, we compared the results with those of sham group. Results：Using this device, we revive neurobehavioral changes(decreased reflexes, hemiparesis, decreased vestibulo-motor function) occuring after human head trauma. Conclusion：In our opinion, this is a very useful experimental head trauma model and will be helpful to many head trauma researchers.

Keywords

References

  1. Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, et al：Therapeutic benifit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32：1005-1011,2001 https://doi.org/10.1161/01.STR.32.4.1005
  2. Diamond DM, Park CR, Heman KL, Rose GM：Exposing rats to a predator impairs spatial working memory in the radial arm water maze. Hippocampus 9：542-552, 1999 https://doi.org/10.1002/(SICI)1098-1063(1999)9:5<542::AID-HIPO8>3.0.CO;2-N
  3. Dixon CE, Hayes RL：Fluid percussion and cortical impact models of traumatic brain injury in Narayan RK, Wilberger JR, Povlishock JT：Neurotrauma, ed 1. New York：McGraw-Hill, 1996, pp1337-1346
  4. Hamm RJ, Dixon CE, Gbadebo DM, Singha AK, Jenkins LW, Lyeth BG, et al：Cognitive deficit following traumatic brain injury produced by controlled cortical impact. J Neurotrauma 9：11-20, 1992 https://doi.org/10.1089/neu.1992.9.11
  5. Hamm RJ, Pike BR, O’dell DM, Lyeth BG, Jenkins LW：The rotarod test：An evaluation of its effectiveness in assessing motor deficit following traumatic brain injury. J Neurotrauma 11：187-196, 1994 https://doi.org/10.1089/neu.1994.11.187
  6. Hamm RJ：Neurobehavioral assessment of outcome following traumatic brain injury in rats：An evaluation of selected measures. J Neurotrauma 18：1207-1216, 2001 https://doi.org/10.1089/089771501317095241
  7. Markgraf CG, Clifton GL, Auirre M, Chaney SF, Bois CK, Kennon K, et al：Injury severity and sensitivity to treatment after controlled cortical impact in rats. J Neurotrauma 18：175-186,2001 https://doi.org/10.1089/08977150150502604
  8. Paxinos G, Watson C：The rat brain in stereotactic coordinates, ed 2. San Diego：Academic press, 1986, figure 1-43