A Clinical Study of Facial Wrinkles Affected by Facial Expression Muscles Treated with Botulinum Toxin(Botox$^{(R)}$)

보툴리눔 독소(보톡스$^{(R)}$)로 치료한 얼굴 주름의 임상적 고찰

Youn, Sang-Woong;Seo, Koo-Il;Yoo, Jong-Yeop;Park, Kyoung-Chan;Eun, Hee-Chul
윤상웅;서구일;유종엽;박경찬;은희철

  • Published : 20020400

Abstract

Background : Botulinum toxin type A is being widely used for the treatment of facial wrinkles affected by facial expression muscles. Due to the sudden and exponential surge in popularity of its use for facial wrinkles, there are scanty reports of facial wrinkles treated with botulinum toxin type A especially in Asians. Objective : This study was performed to investigate the clinical features of facial wrinkles affected by facial expression muscles and the effects of botulinum toxin A on the treatment of wrinkles. Methods : Medical records of 61 patients with facial wrinkles treated with botulinum toxin type A were reviewed. Demographic profiles of the patients, the age of onset of facial wrinkle, the distributions of facial wrinkles, treatment dose of botulinum toxin type A, side effects, and follow up data were analyzed. Results : Female patients were predominant(93.4%) than male patients(6.6%). The mean age of the patients was 41.3 years. Crow's feet were the most frequently treated site of facial wrinkles. Average number of treated sites were 2.38. Side effect profiles were similar as previous reports in Caucasians. The number of patients who took the regular retreatment was less than expected. Conclusion : The clinical profiles of wrinkle patients in Koreans treated with botulinum toxin A were assessed. We think it is one of the effective treatment modalities for antiwrinkling.

Keywords

References

  1. Yaar Mla, Gilchrest BA. Aging of skin. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, et ai, editors. Dermatology in general medicine. 5th ed. New York: McGraw-Hill, 1999:1697-1706
  2. Wieder JM, Moy RL. Understanding botulinum toxin. Dermatol Surg 1998;24:1172-1174 https://doi.org/10.1016/S1076-0512(98)00190-3
  3. Carruthers A, Carruthers J. Botulinum toxin type A: history and current cosmetic use in the upper face 2001;20:71-84
  4. Fulton JE. Botulinum Toxin : the Newport beach experience. Dermatol Surg 1998;24:1219-1224 https://doi.org/10.1016/S1076-0512(98)00184-8
  5. Caruthers A, Carruthers J. Clinical indications and injection technique for the cosmetic use of botulinum A exotoxin. Dermtol surg 1998;24:1189-1194 https://doi.org/10.1016/S1076-0512(98)00189-7
  6. Matarasso SL. Complications of botulinum A exotoxin for hyperfunctional lines. Dermatol Surg 1998;24:1249-1254 https://doi.org/10.1016/S1076-0512(98)00187-3
  7. Carruthers A, Carruthers J. History of the cosmetic use of botulinum A exotoxin. Dermatol Surg 1998;24:1168-1170 https://doi.org/10.1016/S1076-0512(98)00177-0
  8. Griffiths CEM, Wang TS, Hamilton TA, Voorhees JJ, Ellis CN. A photonumeric scale for the assessment of cutaneous photodamage. Arch Dermatol 1992;128:347-351 https://doi.org/10.1001/archderm.128.3.347
  9. Larnier C, Ortonne J-P, Venot A, Faivre B, Beani J-C, Thomas P, et al. Evaluation of cutaneous photodamage using a photographic scale. Br J Dermatol 1994;130:167-173 https://doi.org/10.1111/j.1365-2133.1994.tb02895.x
  10. Chung JH, Lee SH, Youn CS, Park BJ, Kim KH, Park KC, et al. Cutaneous photodamage in Koreans : influence of sex, sun exposure, smoking, and skin color. Arch Dermatol 2001;137:1043-1051
  11. Heckmann M, Schon-Hupka G. Quantification of the efficacy of botulinum toxin type A by digital image analysis. J Am Acad Dermatol 2001;45:508-514 https://doi.org/10.1067/mjd.2001.116216
  12. Binder WJ, Blitzer A, Brin MF. Treatment of hyperfunctional lines of the face wit botulinum toxin A. Dermatol Surg 1998;24:1198-1205 https://doi.org/10.1016/S1076-0512(98)00181-2
  13. Klein AW, Wexler P, Carruthers A, Carruthers I. Treatment of facial furrows and rhytides. Dermatol Clin 1997;15:595-607 https://doi.org/10.1016/S0733-8635(05)70469-1
  14. Carucci JA, Zeibel SM. Botulinum A exotoxin for rejuvenation of the upper third of the face. Facial Plastic Surg 2001;17:11-20 https://doi.org/10.1055/s-2001-16362
  15. Blitzer A, Binder WJ. Current practices in the use of botulinum toxin A in the management of facial lines and wrinkles. Facial Plast Surg Clin North Am 2001; 9:395-404
  16. laude Le Lauarn. Botulinum toxin A and facial lines :the variable concentration. Anesth Plast Surg 2001;25:73-84 https://doi.org/10.1007/s002660010100
  17. Khawaja HA, Hernandez-Perez E. Botox in dermatology. Int J Dermatol 2001;40:311-317 https://doi.org/10.1046/j.1365-4362.2001.01176.x
  18. Allergan Inc., Irvine CA. Product Literature (packageinsert) on Botox. 1995