Journal of the Korean Orthopaedic Association (대한정형외과학회지)

Korean Orthopaedic Association (대한정형외과학회)
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Changes of Serum Alkaline Phosphatase and Osteocalcin during Fracture Healing

골절 치유 과정의 혈청 내 Alkaline Phosphatase와 Osteocalcin의 변화

Lee, Ho-Seung;Lee, Choon-Sung;Jang, Jae-Suk;Lee, Jae-Dam;Um, Sung-Moon
이호승;이춘성;장재석;이재담;엄성문

  • Published : 20020000
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Abstract

Purpose : To investigate changes of serum osteoblastic marker during fracture healing. Materials and Methods : The study included 22 patients with fresh fractures. Serum alkaline phosphatase (ALP), bone specific alkaline phosphatase and osteocalcin were analyzed on the first day and 1, 2, 4 and 8 weeks after injury. The bone specific-ALP was quantified by electrophoresis. Osteocalcin was quantified by enzyme linked immunosorbent assay (ELISA). Results : One, 2, 4 and 8 weeks after injury, mean values of serum ALP increased 1.26, 1.45, 1.63, and 1.2 times that on the first day after injury, respectively. Similarly, during the same period, bone specific ALP increased 1.38, 1.33, 1.73 and 1.25 times, and serum osteocalcins increased 1.32, 1.2, 1.64 and 2.09 times. Conclusion : Serum ALP increased during the early soft callus phase. However, serum osteocalcins increased during the late hard callus phase. Serum alkaline phosphatase and osteocalcin warrant further study as useful prognostic indicators of fracture healing.

목 적 : 골절 후 비교적 측정이 용이한 골 형성 지표인 혈청 내 alkaline phosphatase와 osteocalcin의 변화를 분석하여 생화학적 측면에서 골절 치유 과정을 알아보고 이들이 골 형성 및 골 유합을 예측할 수 있는 객관적인 지표로 이용될 수 있는지 알아보고자 하였다. 대상 및 방법 : 22예의 골절 환자에서 수상 직후, 수상 후 1주, 2주, 4주, 8주때의 혈청 내 alkaline phosphatase, bone specific alkaline phosphatase, osteocalcin 등의 골형성 지표의 증가 정도를 비교 분석하였다. 결 과 : 혈청 내 alkaline phosphatase는 수상 직후부터 오르기 시작하여 4주경 가장 높게 나타났으며 osteocalcin은 수상 후 1주 때부터 점차로 증가하여 8주 때 가장 높게 나타났다. 결 론 : 골절 치유 과정에서 혈청 내 alkaline phosphatase와 osteocalcin이 증가 시기에 있어 차이를 보이는 이유는 먼저 골 기질이 성숙되는 시기에 alkaline phosphatase가 증가하고 이 후 무기질화가 진행되며 osteocalcin이 주로 발현되기 때문이며 이러한 골 형성 지표의 변화는 골절 치료에 있어 치료 방법을 결정하거나, 어떤 약물이나 치료 방법의 효과를 평가하는 또 다른 지표가 될 수 있을 것이다.

Keywords

References

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