Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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Characterization of a Streptomycete Isolate Producing the Potent Cytotoxic Substance, Nonadecanoic Acid

  • Seong, Chi-nam (Department of Biology, Sunchon National University, Sunchon, 540-742) ;
  • Baik, Keun-shilk (Department of Biology, Sunchon National University, Sunchon, 540-742) ;
  • Jo, Jung-sun (Department of Biology, Sunchon National University, Sunchon, 540-742) ;
  • Yoo, Jin-cheol (Department of Pharmacy, Chosun University, Gwangju, 501-759) ;
  • Han, Ji-Man (Department of Pharmacy, Chosun University, Gwangju, 501-759) ;
  • Nam, Seung-Kwon (Department of Pharmacy, Chosun University, Gwangju, 501-759)
  • Published : 2002.06.01
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Abstract

Streptomycete isolator strain M0137 showed cytotoxic effect on THP-1 cells. One of the purified substances produced from the strain was identified as nonadecanoic acid. Morphological and physiological properties, phylogenetic analysis, and genomic fingerprinting of strain M0137 were determined. Strain M0137 showed a high similarity with Streptomyces scabiei, phenotypically and phylogenetically. In contrast, genomic fingerprinting and G+C content analysis revealed that strain M0137 could be distinguished from S. scabiei ATCC49173$\^$T/. We propose to name strain M0137 as Streptomyces scabiei Subsp.

Keywords

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