The Effects of Smoking, Drinking and Exercise on Autioxidant Vitamin Intakes and Plasma Antioxidant Status in Elderly People Living in Ulsan

울산지역 노인의 생활습관에 따른 항산화 영양소 섭취실태 및 혈액내 항산화 영양 상태 비교

  • 김미정 (서울여자대학교 식품과학부 식품영양학) ;
  • 김옥현 (서울여자대학교 식품과학부 식품영양학) ;
  • 김정희 (서울여자대학교 식품과학부 식품영양학)
  • Published : 2002.08.01

Abstract

Body antioxidant status is an important factor in the prevention of many chronic diseases caused by oxidative stress, especially in the elderly and is affected by health-related habits, such as smoking, drinking and regular physical activity. The aim of this study was to investigate the relationship between these health-related habits and plasma antioxidant status in the elderly. Plasma antioxidant status was examined by determining plasma levels of antioxidant vitamins (vitamin C, A, E, $\beta$ -carotene), total antioxidant status (TAS) and thiobarbituric acid-reactive substance (TBARS) . The subjects included 225 elderly persons aged over 60 yews (63 males, 162 females) living in the Ulsan area. They were interviewed to collect data on their general characteristics and health behaviors such as smoking, exercise and alcohol consumption by means of questionnaires. Their dietary intakes were obtained by means of semi-quantitative food frequency questionnaires (FFQ) The study population was divided into two or three groups according to their smoking, drinking, and exercise status. The ratio of smoker, drinker and exerciser was 16.7%, 31.0% and 44.2% respectively. The dietary antioxidant vitamin intakes were not significantly different among groups of smoking and drinking status, but tended to be higher in non-smokers and non-drinkers than in smokers and drinkers. Plasma vitamin C and $\beta$ -carotene levels were significantly higher in non-smokers, but Plasma vitamin A and TBARS levels were significantly lower in non-smokers than in smokers. Plasma TAS was not significantly different among the smoking groups, but showed a tendency to decrease with an increase in the number of packyear. Plasma vitamin C and $\beta$ -carotene levels of the non-drinkers were higher than those of drinkers and past-drinkers, but plasma vitamin A, C, E, TAS and TBARS showed no difference among the groups of drinker. All vitamin intakes of the exercisers were slightly higher than those of the non-exercisers, but vitamin C intake was significantly higher in female exercisers than in non-exercisers. Plasma $\beta$ -carotene levels were significantly higher in male exercisers and plasma vitamin A, C, E, TAS and TBARS levels tended to be higher in exercisers than in non-exercisers. These results suggested that change to non-smoker, modulation of alcohol consumption and regular exercise could enhance antioxidant defences against reactive oxygen species and might increase the likelihood of a healthier life span.

Keywords

References

  1. Allard JP, Rpyall D, Kurian R, Muggli R (1994): Effects of betacarotene supplementation on lipid peroxidation in humans. Am J Clin Nutr 59: 884-890
  2. Ames BN, Shigenaga MK, Hagen TM (1993): Oxidants, antioxidants, and the degenerative disease of aging. Proc Natl Acad Sci USA 90: 7915-7922
  3. Baek JW, Koo BK, Kim KJ, Lee YK, Lee SK, Lee HS (2000): Nutritional status of the long-lived elderly people in Kyungpook Sung-Ju area (I) - Estimation of nutrients intakes. Korean J Nutr 33 (4): 438-453
  4. Berlin JA, Colditz GA (1990): A meta-analysis of physical activity in the prevention of coronary heart disease. Am J Epidemiol 132: 612-628
  5. Bieri JG, Brown ED, Smith JC (1985): Determination od individual carotenoid in human plasma by high performance liquid chromatography. J Liq Chrom 8 (3): 474-484
  6. Bieri JG, Tolliver TJ, Catignani GL (1979): Simultaneous determination of alpha-tocopherol and retinol in plasma or red blood cells by high pressure liquid chromatography. Am J Clin Nutr 32: 2143-2149
  7. Bolton-Smith C, Casey CE, Gey KF, Smith WCS, Tunstell-Pedoe H (1991): Antioxidant vitamin intakes assessed using a food-frequency questionnaire: Correlation with biochemical status in smokers and non-smokers. Br J Nutr 65: 337-346
  8. Brown KM, Morrice PC, Duthie GG (1997): Erythrocyte vitamin E and plasma ascorbate concentration in relation to erythrocyte peroxidation in smokers and nonsmokers: dose response to vitamin E supplementation. Am J Clin Nutr 52 (2): 145-150
  9. Cade JE, Margetts BM (1991): Relationship between diet and smoking: Is the diet of smokers different? J Epidemiol Community Health 45: 270-272
  10. Cho YS, Lim HS (1991): A survey on the food habit and health of the aged in middle city. Korean J Nutr 12(4): 346-353
  11. Chon JH, Shin MH (1998): Some vitamin status in healthy elderly Korean urban housebolds. Korean J Nutr 21 (4): 253-359
  12. Duthie GG, Wahle KWJ, James WPT (1989): Oxidants, antioxidants and cardiovascular disease. Nutrition Research Reviews 2: 51-62
  13. Faruque O, Khan MR, Rahman M, Ahmed F (1995): Relationship between smoking and antioxidant nutrient status. Br J Nutr 73: 625-632
  14. Frei B, Stocker R, Ames BN (1989): Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci USA 86: 6377-6381
  15. Gleeson M, Robertson JD, Maughan RJ (1987): Influence of exercise on ascorbic status in man. Clin Sci (Colch) 73: 501-505
  16. Gronbaek M, Becker U, Johansen D (2000): Type of alcohol consumed and mortality from all cause, coronary heart disease, and cancer. Ann Intern Med 133: 411-419
  17. Halliwell B, Cross CE (1994): Oxygen-derived species: their relation to human disease and environmental stress. Environ Health Perspect 102 (suppl): 5-12
  18. Handelman GJ, Packer L, Cross CE (1996): Destruction of tocopherols, carotenoids and retinol in human plasma by cigarette smoke. Am J Clin Nutr 63 (4): 559-565
  19. Ji LL (1995): Exercise and oxidative stress: role of cellular antioxidant systems. In: Holloszy JO, ed. Exercise and sport sciences reviews, pp.135-166, Baltimore: William & Wilkins
  20. Ji LL (1999): Antioxidants and oxidative stress in exercise. Proc Soc Exp Biol Med 222(3): 283-292
  21. Kang MH, Park EJ (2000): Effects of regular physical exercise habits on the activities of erythrocyte antioxidant enzyme and plasma total radical-trapping antioxidant potential in healthy male subjects. Korean J Nutr 33 (3): 289-295
  22. Kesse E, Clavel-Chapelon F, Slimani N, van Liere M, the E3N Group (2001): Do eating habits differ according to alcohol consumption? Results of a study of the French cohort of the European Prospective Investigation into Cancer and Nutrition (E3N-EPIC). Am J Clin Nutr 74: 322-327
  23. Kim SH, Kang HK, Kim JH (2000): Socio-economic factors affecting the health and nutrtional status of the aged. Korean J Nutr 33(1): 86-101
  24. Kiningham RB (1998): Physical activity and the primary prevention of cancer. Prim Care 25: 515-536
  25. Kitamura Y, Tanaka K, Kiyohara C, Hirohata T, Tomita Y, Ishibashi M, Kido K (1997): Relationship of alcohol use, physical activity and dietary habits with serum carotenoids, retinol and alpha-tocopherol among male Japanese smokers. lnt J Epidemiol 26: 307-314
  26. Lecomte E, Herbeth B, Pirollet P, Chancerelle Y, Arnaud J, Musse N, Paille F, Siest G, Artur Y (1994): Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators
  27. Lee IM (1995): Exercise and physical health: cancer and immune function. Res Q Exerc Sport 66: 286-291
  28. Malone WF (1991): Studies evaluationg antioxidants and $\beta$-carotene as chemopreventives. Am J Clin Nutr 53: 383S-385S
  29. Mayne ST, Janerich DT, Greenwald P, Chorost S, Tucci C, Zaman MB, Melamed MR, Kiely M, Mckneally MF (1994): Dietary beta carotene and lung cancer risk in US nonsmokers. J Natl Cancer Inst 86: 33-38
  30. Meydani M, Evans WJ, Handelman G (1993): Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults. Am J Physiol 264: 992-998
  31. Midgetts AS, Baron JA, Roban TE (1993): Do cigarette smokers have diets that increase their risk of coronary heart disease and cancer? Am J Epidemiol 137 (5): 521-529
  32. Miller NJ, Rice-Evans C, Davies MI, Gopinathan V, Milner AA (1993): A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci 84: 407-412
  33. Niki E (1991): Acton of ascorbic acid as scavenger of active and stable oxygen radicals. Am J Clin Nutr 54: 1119S-1124S
  34. Nomura AMY, Stammermann GN, Heibrun LK (1985): Serum vitamin levels and the risk of cancer of specific sites in men of Japanese ancestry in Hawaii. Cancer Res 43: 2369-2372
  35. NRC (National Research Council) (1980): Recommended dietary allowances, 9th ed
  36. Ohkawa H, Ohishi N, Aogi K (1979): Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351
  37. Pesce AJ, Kaplan LA (1987): Methods in clinical chemistry. The CV Mosby-Company, St. Louis Washington. DC Toronto. Part 10, Chapter 75: 574-581
  38. Powers SK, Hamilton K (1999): Antioxidants and exercise. Clin Sports Med 18(3): 525-536
  39. Pryor WA (1991): Can vitamin E protect hmans agaist the pathological effects of ozone in smog? Am J Clin Nutr 53: 702-722
  40. Pryor WA (1997): Cigarette smoke radical s and the role of free radicals in chemical carcinogenecity. Environ Health Perspect 4: 875-882
  41. Rimm EB, Klatsky A, Grobbee D, Stampfer MJ (1996): Review of moderate alcohol consumption and reduced risk of coronary heart disease: Is the effect the beer, wine or spirits? BMJ 312: 731-736
  42. Sen CK (1995): Oxidants and antioxidants in exercise. J Appl Physiol 79: 675-686
  43. Shumidt K (1991): Antioxidant vitamins and $\beta$-carotene: effects on immunocompetence. Am J Clin Nutr 53: 383S-385S
  44. Thun MJ, Peto R, Lopez AD (1997): Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 24: 1705-1714
  45. Toniolo P, Riboli E, Cappa AP (1991): A community study of alcohol consumption and dietary habits in middle-aged Italian women. Int J Epidemiol 20: 663-670
  46. Ward RJ, Jutla J, Peters TJ (1989): Antioxidant status in alcoholic liver disease. Adv Biosci 76: 343-351