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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Antitumor Effects of the Hexane Extract of Stachys Sieboldii MIQ

초석잠 추출물의 항암 및 면역 효과

  • 류병호 (경성대학교 식품공학과) ;
  • 박법규 (경성대학교 식품공학과) ;
  • 송승구 (부산대학교 화학공학과)
  • Published : 2002.12.01
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Abstract

The present study was designed to investigate the effects of Stachys Sieboldii MIQ as a new natural antitumor agent or immunomodulator. To obtain the above objectives, Stachys sieboldii MIQ was extracted with ethanol. Stachys sieboldii MIQ accelerated mouse spleen cell growth, but inhibited FM3A/S°-cell growth. However, no significant difference was found for CD4+ / CD8+ cells. The growth rates of CD4+ and CD8+ T cells were accelerated more than those normal mouse group. Stachys sieboldii MIQ fed mice showed a significant enhancement of IL-2 receptor expression, increased numbers of CD4+ T cells, and CD8+ T cells. Stachys sieboldii MIQ also stimulated the production of NO by peritoneal macrophages and the production of NO by and the growth of mouse spleen cells. On the other hand, lung localization of Bl6Fl0 melanoma cells was inhibited by ethanol extract of Stachys sieboldii MIQ. These results show that Stachys sieboldii MIQ is a useful new functional antitumor agent or immunomodulator.

초석잠의 항암효과 및 면역조절자로서의 기능을 알아보기 위하여 마우스를 이동하여 실험한 결과, 마우스 비장세포의 증식반응은 항진시켰으나 YAC-1 세포주의 증식능은 억제시켰다. CD4+ T세포 및 CD8+ T세포의 비율이 정상 대조군 마우스의 그것에 비하여 증가하였으나 CD4+/CD8+ 비는 차이가 없었으며 비장세포에서 IL-2수용체의 발현이 항진되었다. 또한, 복강대식세포로부터의 nitric oxide와 TNF-$\alpha$ 생산을 항진시켰으며, 복강대식세포는 탐식능이 현저하게 항진되었고 B16F10 흑색종의 폐전이가 억제됨을 알 수 있었다. 따라서, 초석잠의 항암제 및 면역반응 조절자로서의 개발 가능성이 있음을 시사한다.

Keywords

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