The Development of Exposure Assessment Tools for Risk Assessment of Volatile Organic Compounds

VOCs의 위해성 평가를 위한 노출분석 방법 연구

  • Jo, Seong-Joon (Institute for Envrionmntal Research Yonsei(IERY), Yonsei University) ;
  • Shin, Dong-Chun (Institute for Envrionmntal Research Yonsei(IERY), Yonsei University) ;
  • Chung, Yong (Institute for Envrionmntal Research Yonsei(IERY), Yonsei University) ;
  • Lee, Duck-Hee (Institute for Envrionmntal Research Yonsei(IERY), Yonsei University) ;
  • Breysse, Patrick N. (Johns Hopkins University, Bloomberg School of Public Health, Department of Environmental Health Sciences)
  • 조성준 (연세대학교 환경공해연구소) ;
  • 신동천 (연세대학교 환경공해연구소) ;
  • 정용 (연세대학교 환경공해연구소) ;
  • 이덕희 (연세대학교 환경공해연구소) ;
  • Published : 2002.06.01

Abstract

Volatile organic compounds (VOCs) are an important public health issue in Korea and many important questions remain to be addressed with respect to assessing exposure to these compounds. Because they are ubiquitous and highly volatile, special techniques must be applied in their analytic determination Valid Personal exposure assessment methods are needed to evaluate exposure frequency, duration and intensity, as well as their relationship to personal exposure characteristics. Biological monitoring is also important since it may contribute significantly in risk assessment by allowing the estimation of effective absorbed doses. This study was on ducted to establish the environmental measurement, personal dosimetry and biological monitoring methods for VOCs. These methods are needed to compare blood, urinary and exhalation breath VOC levels and to provide tools for risk assessment of VOC exposure. Passive monitors (badge type) and a active samplers (trap) for the VOCs collection were used for air sampling. Methods development included determining the minimum detectable amounts of VOCs in each media, as well as evaluating collection methods and developing analytical procedures. Method reliability was assessed by determining breakthrough volumes and comparing results between laboratories and with other methods. A total capacity of trap used in this study was 60ι. Although variable by compound, the average breakthrough was 20%. Also, there was no loss of compounds in trap even if keep for 45 day in -7$0^{\circ}C$. The recovery of active and passive methods was 69% ~ 126% and method detection limit was 0.24 $\mu\textrm{g}$/trap and 0.07 $\mu\textrm{g}$/badge. There was no statistical difference (P > 0.05) between active and passive methods.

Keywords

References

  1. 3M. Instruction, for use organic vapor monitors # 3520/3530. 3M occupational health and environmental safety division. Paul St, MN, 1991
  2. Ashley DL, Bonin MA, Cardinali FL, McCraw JM, Holler JS, Needham LL, and Patterson DG. Determing volatile organic compounds in human blood from a large sample population by using purge and trap gas chromatography/mass spectrometry. Anal Chem 1992; 64: 1021-1029 https://doi.org/10.1021/ac00033a011
  3. Bloemen HJ, and Bum J. Chemistry and analysis of volatile organic compounds in the environment. Blackie academic & professional 1993; 1-2
  4. Cohen MA, Ryan PB, Yanagisawa Y, and Hammond SK. The validation of paassive sampler for indoor and outdoor concentrations of volatile organic compounds. J Air & Waste Manage Assoc. 1990; 40: 993-997 https://doi.org/10.1080/10473289.1990.10466751
  5. Cohen MA, Ryan PB, Yanagisawa Y, Spengler JD, zkaynak H, and Epstein PS. Indoor/outdoor measurements of volatile organic compounds in the Kanawha Valley of West Virginia. JAPCA 1989; 39 : 1089-1093
  6. EPA. Federal register-rules and regulations. 49(209): 198-199,1984
  7. EPA. Compendium of methods for the determination of toxic organic compounds in ambient air, Second Edition Compendium method TO-17, determination of volatile organic compounds in ambient air using active sampling onto sorbent tubes: Center for environmental research information office of research and development: US EPA: Cincinnati OH, 1997
  8. Fawell JK, and Hunt S. Environmental toxicology; Organic pollutants. John Wiley & Sons. NY, 1988
  9. Fellin P, and Ottson R. Seasonal levels of volatile organic compounds (VOCs) in canadian homes. Indoor air 93; Proceedings of the 6th international conference on indoor air and climate 1993; 2: 117-122
  10. Girman JR, Hodgson AT, and Wind ML. Considerations in evaluating emissions from consumer products. Atmos. Environ 1987; 21: 315-320 https://doi.org/10.1016/0004-6981(87)90007-2
  11. Guerin MR, Higgins CE, and Jenkins RA. Measuring environmental emissions from tobacco combustion: sidestream cigarette smoke literature review. Atmos. Environ 1987; 21: 291-297 https://doi.org/10.1016/0004-6981(87)90004-7
  12. Helmig D, and Greenberg JP. Automated in situ gas chromatographic-mass spectrometric analysis of ppt level volatile organic trace gases using multistage solid - adsorbent trapping. Journal of chromatography a 1994; 677 : 123-132 https://doi.org/10.1016/0021-9673(94)80551-2
  13. Jermini C, Weber A, and Grandjean E. Quantitative determination of various gas -phase components of the sidestream smoke of cigarettes in room air (in german). International Archives Occupational and Environmental Health 1976; 36: 169-181 https://doi.org/10.1007/BF00378272
  14. Jongeneelen FJ. Biological exposure limit for occupational exposure to coal-tar pitch volatiles at coke-ovens. International Archives Occupational and Environmental Health 1992; 63: 511-516 https://doi.org/10.1007/BF00386338
  15. Lindstrom AB, Pleil JD, and Berkoff DC. Alveolar breath sampling and analysis to assess trihalomethane exposures during competitive swimming training. Environmental Health Perspectives 1997; 105(6): 636-642 https://doi.org/10.2307/3433609
  16. Lioy PJ. Airborne toxic elements and organic substances (ATEOS) Project: overview. Toxicology and Industrial Health. 1990; 6(5): 53-65
  17. Lioy PL, Daisey JM. The New Jersey project on airborne toxic elements and organic substance JAPCA 1983; 33 (7):647-657
  18. M∅lhave L. Indoor Air Pollution due to organic gases and vapours of solvents in building materials. Environ. Int. 1982; 8: 117-127 https://doi.org/10.1016/0160-4120(82)90019-8
  19. Morandi MT, Stock TH, Chung CW, Kim Y, and Afshar M. Field comparison of canisters, continuous GC and Passive Dosimeters for VOCs using 24-hour exposure periods. Indoor Air 93; Proceedings of the 6th International Conference on Indoor Air and Climate, 1996
  20. National academy of sciences. Human exposure assessment for airborne contminants advances and opportunities. National Academy Press, Washington D.C., 1991
  21. Ottson R, Fellin P, and Tran Q. Investigation of VOCs in canadian residences. Indoor Air 93; Proceedings of the 6th International Conference on Indoor Air and Climate 1993; 2: 141-146
  22. Patrick DR. Toxic air pollution handbook. Van Noatranb Reinhold. NC, 1994
  23. Pellizzari ED. Personal communication. Triangle Institute, Research Triangle Park, NC, 1994
  24. Samet JM, and Spengler JD. Indoor air pollution: a health perspective. The Johns Hopkins University Press, 1991
  25. Seifert B, Mailahn C, Schulz C, and Ullrich D. Seasonal variation of concentrations of volatile organic compounds in selected german homes. Environ. Int. 1989; 15: 397-409 https://doi.org/10.1016/0160-4120(89)90054-8
  26. Stock TH, Morandi MT, and Afshar M. Modified diffusion sampler for measuring 24-hour VOC concentration in personal, indoor and community air. Indoor Air 93; Proceedings of the 6th International Conference on Indoor Air and Climate, 1996
  27. Wallace LA, and O'Neill IK. Personal air and biological monitoring of individuals for exposure to environmental to tabacco smoke. In Environmental Cacinogenesis: Selected methods of analysis: Passive Smoking. International Agency for Research on Cancer (IARC), Lyon, France 1987; 9(7)
  28. Wallace LA, Pellizzari E, Hartwell T, Rosenzweg M, Erickson M, Sparacino C, and Zelon H. Personal exposure to volatile organic compounds: i. direct measurements in breathing-zone air, drinking water, food and exhaled breath. Environmetal Research 1984; 35: 293-319 https://doi.org/10.1016/0013-9351(84)90137-3
  29. Wallace LA. VOCs and the environmental and public health -exposure: Blomen H.J.Th., and Burn J. : (Edi). Chemistry and analysis of volatile organic compounds in the environment: Chapter l. London. Blackie Academic & Progessional. 1993
  30. Yanagisawa Y, and Hirano K. Methodology to evaluate passive samplers. Indoor Air 93; Proceeding of the 6th International Conference on Indoor Air and Climate, 1996