YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Isolation of the Efficacy Constituent for Neuronal Regeneration from Cibotium barometz

구척으로부터 신경재생 효능 성분 분리

  • Published : 2002.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

A phytochemical study on the root of Cibotium barometz J. Smith led to the isolation of onitin (I), daucosterol (II) and a new compound (III). Compound III was characterized as 2-Ο-(9Z,12Z-octadecadienoyl)-3-Ο-[$\alpha$-D-galactopyranosyl-(1"-6")-Ο-$\beta$-D-galactopyranosyl] glycerol, named shinbarometin by $^1$H-, $^{13}$ C-NMR and LC/MS data. Compound III exerted an induced neuronal regeneration on nogo-A induced neuroblastoma cells.

Keywords

References

  1. ‘Directory of Chinese Materia Medica' (Zhong Yao Da Ci Dian or 中藥大辭典) ed. by Jiansu New Medical College, Shanghai Scientific and Technollgical Publisher, Shanghai, p.1420 (1977)
  2. Namba, T. The Encyclopedia of Wakan-Yaku with Color Pictures(I), Hoikusha Pub. Co., Osaka, 86 (1993)
  3. Murakami, T., Satake, T., Ninomiya K., Iida, H., Yamauchi, K., Tanaka, N., Saiki, Y., and Chen, CM. : Pterosin-derivate aus der Famile Pteridaceae. Phytochemistry 19, 1743 (1980)
  4. Yang, M. S. : Studies on the Taiwan fork medicine VI. Studies on onitin. Planta Medica p 25 (1986)
  5. Chen, M. S., Huber, A. B., van der Haar, M. E., Frank, M., Schnell, L., Spillmann, A. A., Christ, E, and Schwab, M. E. : Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434 (2000)
  6. GrandPre, T., Nakamura, F., Vartanian, T., and Strittmatter, S. M. : Identification of the nogo inhibitor of axon regeneration as a reticulon protein. Nature 403, 439 (2000)
  7. Prinjha, R., Moore, S. E., Vinson, M., Blake, S., Morrow, R., Christie, G., Michalo rich, D., Simmons, D. L., and Walsh, F. S. : Neurobiology, Inhibitor of neurite outgrowth in humans. Nature 403, 383 (2000)
  8. Tessier-Lavigne, M., and Goodman, C. S. : Perspectives neurobiology. regeneration in the nogo zone. Science 287, 813 (2000)
  9. Domeniconi, M., Cao, Z., Spencer, T., Sivasankaran, R., Wang, K., Nikulina, E., Kimura, N., Cai, H., Deng, K., Gao, Y., He, Z., and Filbin, M. : Myelin-associated glycoprotein interacts with the nogo66 receptor to inhibit neurite outgrowth. Neuron 35, 283 (2002)
  10. Wickelgren, D. : Neuroscience. Animal studies raise hopes for spinal cord repair. Science 297, 178 (2002)
  11. Liu, B. P., Fournier, A., GrandPre, T., and Strittmatter, S. M. : Myelin-associated glycoprotein as a functional ligand for the nogo-66 receptor. Science. 297, 1190 (2002) https://doi.org/10.1126/science.1073031
  12. Wang, K. C., Koprivica, V., Kim, J.A., Sivasankaran, R., Guo, Y., Neve, R. L., and He, Z. : Oligodendrocyte-myelin glycoprotein is a nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941 (2002)
  13. Zuo, J., Neubauer; D., Graham, J., Krekoski, C. A., Ferguson, T. A., and Muir, D. : Regeneration ofaxons after nerve transection repair is enhanced by degradation of chondroitin sulfate proteoglycan. Exp. Neuron 176, 221 (2002)
  14. Stothers, J. B. : carbon-$^{13}NMR$ Spectroscopy. Academic Press, New York (1972)
  15. Jung, J. H., Lee H. K., and Kang, S. S. : Diacylglycerylga-lactosides from Arisaema amurense. Phytochemistry 42, 447 (1996)
  16. Janiga T.A., Rind H. B., von Bartheld C. S. : Differential effects of the trophic factors BDNF, NT-4, GDNF, and IGF-I on the isthmo-optic nucleus in chick embryos. J. Neurobiol Jun 5; 43(3), 289-303 (2000)
  17. Mey J., Rombach N. : Retinoic acid increases BDNF-dependent regeneration of chick retinal ganglion cells in vitro. Neuroreport Nov 26; 10(17), 3573 (1999)