Overall Review on endocrine disruptors

내분비계 장애물질의 개요와 검색법의 고찰

  • Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science and Technology)
  • 류재천 (한국과학기술연구원 생체대사연구센터 독성연구실)
  • Published : 2002.09.30

Abstract

내분비계 장애물질이 환경호르몬이란 용어로 우리들의 실생활에 사용되는 용기 등을 통해 여러 가지 영향을 미치고 있다. 수많은 화학물질들 중에서 환경호르몬은 어떠한 종류의 화학물질이며, 언제 알려지게 되었고, 어떻게 분류되었으며, 이러한 환경호르몬성을 갖는 물질들의 환경호르몬성은 어떠한 연구기법에 의해 검색되는지와 현재까지의 사용실태와 문제점 및 국내외 관련 동향 등을 고찰하여 보았다.

Keywords

References

  1. A Study on Hormone-like (Hormone-mimic) Effects of Exogenous substances. (1997) Japan Chemical Industry Association and Japan Chemical Industry Ecology-Toxicology and Information Center
  2. Andersen H.R., Andersson A.M., Arnold S.F., Autrup H., Barfoed M., Beresford N.A, Bjerregaard P., Christiansen L.B., Gissel B., Hummel R., Jorgensen E.B., Korsgaard B., Le Guevel R., Leffers H , McLachlan J., Moller A, Nielsen J.B., Olea N., Oles-Karasko A, Pakdel F., Pedersen K.L., Perez P., Skakkeboek N.E., Sonnenschein c., Soto Ana M., Sumpter JP., Thorpe S.M., Grandjean P. (1999) Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals. Environ. Health Persp. 107(Suppl 1):89-108
  3. Appraisal of Test Methods for Sex-Hormone disrupting Chemicals capable of affecting the reproductive process; prepared by the MRC. Institute for Environmental and Health for the UK Department of Environment, Transport and Regions, (1998)
  4. Arcaro K.F., Yang Y. Vakharia D.D., Gierthy J.F. (2000) Toxaphene is antiestrogenic in a human breast-cancer cell assay. Toxicology & Environ. Health Part A 59(3):197-210
  5. Arcaro K.F., Yang Y. Vakharia D.D., Gierthy J.F. (2000) Toxaphene is antiestrogenic in a human breast-cancer cell assay. Journal of Toxicology & Environ. Health Part A. 59(3):197-210
  6. Ashby J., Lefevre P.A, Odum J., Tinwell H, Kennedy S.J., Beresford N.A., Sumpter J.P., (1997) Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents. Regul. Toxicol. Pharmacol. 26(1 Pt 1):96-101
  7. Barnes S. Kim H Darley-Usmar V. Patel R. Xu J. Boersma B. Luo M. (2000) Beyond ER alpha and ER beta: Estrogen receptor binding is only part of the isoflavone story. Journal of Nutrition. 130(3):6565- 6575
  8. Beekman J.M., Allan G.F., Tsai S.Y., Tsai M.J., O'Malley B.W. (1993) Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Mol. Endocrinol. 7:1266 -1274
  9. Carlos Sonnenschein and Ana M. Soto (1998) An updated review of environmental estrogen and androgen mimics and antagonists. J. Steroid Biochem. Molec. BioI. 65(1):143 -150
  10. Co-ordination of Endocrine Disrupters Assessment Activities, http://www.oecd.org/ehs/endocrin.htm
  11. Colom., T. (1995) Environmental estrogens; Health implications for Humans and wildlife, Environ. Health Persp.,103(Suppl 7):135-136
  12. Davis, D.L. and Bradlow, H.L. (1995) can Environmental Estrogens Cause Breast Cancer, Sci. Amer. pp.166-172
  13. Endocrine disruptors listed from our stolen future and other references, http://www.nihs.go.jp/hse/environ/sdsubs$_{}$stancesnew.html
  14. Endocrine disruptors research Initiative, http://www.epa.gov/ endocrine
  15. Environmental Estrogens & other hormones, http://www.tmc.tulane.edu/ ecme/ eehome/
  16. Environmental Health Information Service, http://ehis.niehs.nih.gov/
  17. Environmental Oestrogens: Consequences for human health and wildlife. Assessment AI. MRC Institute for Environment and Health, University of Leicester (1995)
  18. EPA: EDSTAC (1998) Draft report, June 12
  19. European Workshop on the Impact of Endocrine Disrupters on Human Health and Wildlife. Report of Proceedings. December 2-4, (1996) Weybridge, UK,P128
  20. Fox, G.A, Gilman, A.P., Peakall, D.B., Anderka, FW. (1978) Behavioural Abnormalities on Nesting Lake Ontario GulIs. J. Wil이. Manage. 43(3):477-483
  21. Fry, D.M. (1995) Reproductive effects in birds exposured to pesticides and industrial chemicals, Environ. Health Persp. 103(Suppl. 7):165-171
  22. Gaido, K. W., Leonard, L. S., Lovell, S., Gould, J. C., Babai, D., Portier, C. J., and Mcdonnell, D. P. (1997) Evaluation of chemicals with endocrine modulating activity in a Yeast-Based steroid hormone receptor gene transcription assay. Toxicol. Appl. Pharmacol. 143:205-212
  23. Garrett S.D., Lee H.A, Morgan M.R.A (1999) A nonisotopic estrogen receptor based assay to detect estrogenic compounds. Nature. Biotechnology (12):1219 -1222
  24. Gilbertson, M., et al., (1991) Great Lakes embryo mortality, edema, and deformities syndrome in colonial fish-eating birds: similarity to chickedema disease. J. Toxicol. Environ. Health 33:455-520
  25. Grainger D,J., Metcalfe J.C. (1996) Tamoxifen : teaching an old drug new tricks. Nat. Med. 2:381-385
  26. Green S, Chambon P. (1991) The estrogen receptor: from perception to mechanism. In : Nuclear hormone receptors : molecular mechanisms, cellular functions, clinical abnormalities(Parker MG, ed). London: Academic Press. pp.15-38
  27. Guillette, L.J., Gross, T.S., Masson, G.R., Matter, J.M., Percival, H.F., and Woodward, A R. (1994) Developmental abnormalities of the gonad and abnonnal sex homone concentrations in juvenile alligators from contaminated and control lakes in Florida, Environ. Health Persp. 102:680-688
  28. Harris, C. A, Henttu, P., Parker, M. G., and Sumpter, J. P. (1997) The estrogenic activity of phthalate esters In vitro, Environ. Health. Perspect. 105(8):802- 811
  29. Hertz, R. (1985) The estrogen problem: retrospect and prospect. In Estrogens in the Environment. II. Influences on Development, ed. J.A Mclachlam. Elsevier Science B.V., Amsterdam. pp.1-11
  30. Hutz RJ. Wimpee BAB. Dasmahapatra A Weber DN. Heimler I. Chaffin CL. (1999) Differential modulation by aromatic hydrocarbon receptor agonist of circulating estradiol-17 beta and estrogen-receptor DNA-binding capability in female rainbow trout (Oncorhynchus mykiss). Zoological Science. 16(1):161-166
  31. Introduction to hormone disrupting chemicals, http://website.lineone.net/ -mwarhurst/
  32. Jordan V.C. (1994) Molecular mechanisms of antiestrogen action in breast cancer. Breast Cancer Res Treat 31:41-52 https://doi.org/10.1007/BF00689675
  33. Kartin, P.M., Horwitz, K.B., Ryan, D.S., McGuire, W.L. (1978) Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology 103:1860 -1867
  34. Kelley S.T., Thackray V.G. (1999) Phylogenetic analyses reveal ancient duplication of estrogen receptor isoforms. J. Mol. Evolution 49(5):609-614
  35. Korach K.S. and Mclachlan J.A. (1995) Techniques for detection of estrogenicity. Environ. Health Persp. 103(Suppl 7):5-8
  36. Krishnan, A, et aI. (1991) Bisphenol-A:An estrogenic substance is released from polycarbonate flasks during auto claving., Endocrinology. 132(8):2279-2286
  37. Kuiper G.G., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., Gustafsson J.A. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 138(3):863-870
  38. Kuiper G.G., Enmark E., Pelto-Huikko M., Nilsson S., Gustafsson J.A. (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc . Natl. Acad. Sci USA. 93(12):5925 - 5930
  39. Landel C.C., Kushner P.J., Greene G. (1995) Estrogen receptor accessory proteins: effects on receptor-DNA interactions. Environ Health Persp. 103(Suppl 7):23-28
  40. Lee, H-S., et al., (2002) Empolyment of the human estrogen receptor B1igand-binding domain and co-activator SRCl nuclear receptor-binding domain for the contruction of a yeast two-hybrid detection system for endocrine disrupters. J. Biochern. 131:399-405
  41. Long X.H., Steinmetz R., Ben-Jonathan N. Caperell-Grant A. Young P.C.M., Nephew K.P., Bigsby R.M. (2000) Strain differences in vaginal responses to the xenoestrogen bisphenol A. Environ. Health Persp. 108(3):243-247
  42. McDonnell, D.P., et aI. (1991) High level expression of biologically active estrogen receptor in saccharomyces cerevisiae. J. Steroid Biochem. Mol. Biol. 39:291-297
  43. Metzger, D., et al. (1988) The human oestrogen receptor function in yeast. Nature 334:31-36 https://doi.org/10.1038/334031a0
  44. NIEHS/NTP Research and Interagency Activities on Endocrine Disrupting Chemicals, NIH, USA
  45. Odum J., Lefevra PA, Tittensor S., Paton D., Routledge E.J., Beresford NA, Sumpter J.P., Ashby J., The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay. Regul. Toxieol. Pharmacol. (1997) 25(2):176-88
  46. Paech K., Webb P., Kuiper G.G., Nilsson S., Gustafsson J., Kushner P.J., Scanlan T.S. (1997) Differential ligand activation of estrogen receptors ER-alpha and ER-beta at AP 1 sites. Science 277:1508-10 https://doi.org/10.1126/science.277.5331.1508
  47. Palmer, B.D. and Palmer, S.K. (1995) Vitellogenm induction by xenobiotic estrogens in the red-eared turtle and african clawed frog, Environ. Health Persp. 103(Suppl 4):19-25
  48. Parker M.G., Arbuckle N., Dauvois, Danielian P., White R. (1993) Structure and funtion of the estrogen receptor. Ann NY Acad Sci 684:119-126 https://doi.org/10.1111/j.1749-6632.1993.tb32276.x
  49. Pedraza V. et al. (1991) The E-screen assay: A comparison of different MCF-7 cell stocks, Environ. Health Persp. p.103, pp.844-850
  50. Perez P., Pulgar R., Olea-Serrano F., Villalobos M. Rivas A., Metzler M., Pedraza V. and Olea N. (1998) The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxy groups. Environ. Health Persp. 106(3):167-74
  51. Reel J.R., Lamb I.V.C, Neal B.H. (1996) Survey and assessment of mammalian estrogen biological assays for hazard characterization. Fundam. Appl Toxieol 34(2):288-305 https://doi.org/10.1006/faat.1996.0198
  52. Rehmann K. Schramm K.W. Kettrup A. Chemosphere (1999) Applicability of a yeast oestrogen screen for the detection of oestrogenlike activities in environmental samples. 38(14):3303-3312
  53. Routledge, E. J. and J.P. Sumpter (1997) Structural feature of alkylphenolic chemicals associated with estrogenic activity. J. BioI. Chem. 272:3280-3288
  54. Routledge, E. J., and J.P. Sumpter (1996) Estrogenic activity of surfactant and some of their degradation products assessed using a recombinant yeast screen, Environ. Toxicol. Chem. 15(3):241-248
  55. Schultz, T. W., Seward, J. R., and Sinks G. D. (2000) Estrogenicity of benzophenes evaluated with a recombinant yeast assay: comparison of experimental and rules-based predicted activity. Environ. Toxicol. Chem. 19(2):301-304
  56. Smith D.F., Toft D.O. (1993) Steroid receptors and their associated proteins. Mol. Endocrinol 7:4-11
  57. Smithsonian Institution (1997) International Workshop on endocrine disruptors, Workshop report, Washington D.C. pp.23-24, USA.
  58. Soto Ana M. and Sonnenschein C. (1984) Mechanism of estrogen action on cellular proliferation: evidence for indirect and negative control on cloned breast tumor cells. Biochem Biophys Res. Commun. 16;122(3):1097-1103
  59. Soto Ana M. and Sonnenschein C. (1985) The role of estrogens on the proliferation of human breast tumor cells (MCF-7). J Steroid Biochem.23(1):87-94
  60. Soto Ana M., Fernandez M.F., Luizzi M.F., Oles Karasko A.S. and Sonnenschein C. (1997) Developing a marker of expos따e to xenoestrogen mixtures in human serum. Environ. Health Persp. 105(Suppl 3):647-654
  61. Soto, Ana M., Justica, H., Wray, J. and Sonnenschein, C. (1991) p-Nonylphenol : A estrogenic xenobiotic released from 'Modified' polystyrene, Environ. Health Persp. 92:167-173
  62. Soto, Ana. M., Sonnenschein, C., Chung K. L., Fernandez, M. F., Olea, N., and Serrano, F. O. (1995) The E-SCREEN assay as a tool to identify estrogen: An update on estrogenic environmental ppllutants, Environ. Health. Persp. pp.103-122
  63. Stancel G.M., Boettger-Tong H.L., Chiappetta C, Hyder S.M., Kirkland J.L., Murthy L., Loose-Mitchell D.S. (1995) Toxicity of endogenous and environmental estrogens: what is the role of elemental interactions. Environ. Health Persp. 10(Suppl 7):29-33
  64. Thomas J.A. and H.D. Colby (1997) Endocrine Toxicology, Ed;2nd Ed., Taylor & Francis
  65. Tsai M.J. and O’Malley B.W. (1994) Molecular mechanism of action of steroid/thyroid receptor superfamily members. Ann. Rev. Biochem. 63:451-486
  66. U.S. EPA. (1997) Special report on Environmental Endocrine Disruption: An Effects Assessment and Analysis. Office of Research and Development, EPA/630/R-96/012, Washington D.C.
  67. Vinggaard A.M., Breinholt V. and Larsen J.C. (1999) Screening, of selected pesticides for oestrogen receptor activation in vitro. Food Additives & Contaminants 16(12):533-542 https://doi.org/10.1080/026520399283678
  68. Welcome to EPA's Endocrine Disruptor Screening and Testing Advisory Committee Home, http://www.epa.gov/ opptintr/opptendo
  69. Workshop on the Status of Regulatory and Research Activities on Endocrine Disrupting Chemicals, July 12, Holiday Inn Seoul, Korea, (1999)
  70. Wright, A P. H., Carlstedt-Duke, J. and Gustafsson, J. A (1990) Ligand-specific transactivation of gene expression by a derivative of the human glucocorticoid receptor expressed in yeast. J. BioI. Chem. 265:14763-14769
  71. Yadetie F. Arokwe A Goksoyr A Male R.Induction of hepatic estrogen receptor in juvenile Atlantic salmon in vivo by the environmental estrogen, 4-nonylphenol. Science of the Total Environment. 233(1-3):201-210, 1999
  72. Zava, D. T., and McGurie, W. L. (1978) Androgen activation through estrogen receptor in a human breast cancer cell line. Endocrinology 103:624-631 https://doi.org/10.1210/endo-103-2-624
  73. 내분비계장애물질 중장기 연구사업계획 (38000-67610-57-9961) 환경부, (1999)