Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences

  • Lee, Jung-Hoon (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Lim, Yong-Beom (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Choi, Joon-Sig (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Choi, Myung-Un (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Yang, Chul-Hak (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Park, Jong-Sang (School of Chemistry & Molecular Engineering, Seoul National University)
  • Published : 2003.11.20
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Abstract

Quaternary ammonium groups were introduced to Starburst polyamidoamine (PAMAM) dendrimers for a gene carrier. These quaternary dendritic carriers exhibited reduced cytotoxicity on 293T cells compared to parent dendrimers examined and their transfection efficiency were similar with parent dendrimers. Quaternization could be a promising tool to improve properties of dendrimers as a gene delivery carrier.

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References

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